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Determinants of messenger RNA stability
Cell, 1987The steady-state levels of functional mRNAs are determined in part by their rates of decay in the cytoplasm. Hence, this process plays an important role in the control of gene expression. Individual mRNA species differ widely with respect to metabolic stability.
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RNA Preservation and Stabilization
Biochemistry & Physiology: Open Access, 2014RNA quality and integrity is a prominent issue in gene expression analysis which emerged as a critical tool in life science researches, drug discovery and optimization of bioproduction. Handling and preservation methods including formalin fixation, flash freezing and chemical preservatives (sulfate solution and TRIzol) and commercial compounds ...
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Stabilization of RNA Encapsulated in Silk
ACS Biomaterials Science & Engineering, 2018The use of mRNA and miRNA as diagnostic parameters and therapeutic agents has drawn wide interest both clinically and in research. However, RNA is a labile molecule, which requires strict storage conditions, often including cold temperatures or dry environments, in order to preserve RNA integrity.
Jiuyang He +5 more
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2006
The potential importance of RNA stability to the regulation of chloroplast gene expression is documented by recent work on the molecular aspects of chloroplast biogenesis. In Chlamydomonas reinhardtii, two lines of evidence support the idea that gene-specific regulated RNA decay plays a crucial role in determining the different steady-state levels of ...
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The potential importance of RNA stability to the regulation of chloroplast gene expression is documented by recent work on the molecular aspects of chloroplast biogenesis. In Chlamydomonas reinhardtii, two lines of evidence support the idea that gene-specific regulated RNA decay plays a crucial role in determining the different steady-state levels of ...
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Stability of nucleolar 45-S RNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967Abstract With respect to sedimentation, nucleolar 45-S RNA was stable for 48 h at room temperature in 0.05 M sodium acetate buffer at pH 5.1 and in Tris buffer at pH 9.0 for 2 h. No change in the sedimentation pattern occurred after dialysis, incubation with EDTA or incubation with proteolytic enzymes.
K, Higashi, H, Busch
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1998
The regulation of RNA stability represents one of the key processes determining the level of chloroplast gene expression [1–3]. Several lines of evidence support this idea: 1) Changes in transcription rates alone cannot account for the different transcript levels of plastid genes detected in light versus dark grown higher plants [4, 5].
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The regulation of RNA stability represents one of the key processes determining the level of chloroplast gene expression [1–3]. Several lines of evidence support this idea: 1) Changes in transcription rates alone cannot account for the different transcript levels of plastid genes detected in light versus dark grown higher plants [4, 5].
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RNA Processing and RNA Stability in Plant Mitochondria
2010In angiosperms, mitochondrial genomes encode about 60 genes. The corresponding gene products are all directly or indirectly involved in oxidative phosphorylation indicating their vital function. To realize the mitochondrial genetic information, mitochondria maintain comprehensive genetic systems.
Stefan Binder +2 more
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Poly(A)-assisted RNA decay and modulators of RNA stability.
Progress in molecular biology and translational science, 2009In Escherichia coli, RNA degradation is orchestrated by the degradosome with the assistance of complementary pathways and regulatory cofactors described in this chapter. They control the stability of each transcript and regulate the expression of many genes involved in environmental adaptation.
Ph., Régnier, Hajnsdorf, E.
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