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Control of RNA Stability in Immunity
Annual Review of Immunology, 2021Posttranscriptional control of mRNA regulates various biological processes, including inflammatory and immune responses. RNA-binding proteins (RBPs) bind cis-regulatory elements in the 3′ untranslated regions (UTRs) of mRNA and regulate mRNA turnover and translation.
Kazuhiko Maeda, Shizuo Akira
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The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability
Biochemistry, 2022We examined the complex network of interactions among RNA, the metabolome, and divalent Mg2+ under conditions that mimic the Escherichia coli cytoplasm. We determined Mg2+ binding constants for the top 15 E. coli metabolites, comprising 80% of the metabolome by concentration at physiological pH and monovalent ion concentrations. These data were used to
Jacob P. Sieg +4 more
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RNA Preservation and Stabilization [PDF]
Biochemistry & Physiology: Open Access, 2014 RNA quality and integrity is a prominent issue in gene expression analysis which emerged as a critical tool in life science researches, drug discovery and optimization of bioproduction. Handling and preservation methods including formalin fixation, flash freezing and chemical preservatives (sulfate solution and TRIzol) and commercial compounds ...
Mohammad Najafi, Zahra Salehi
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Seminars in Virology, 1997
Abstract RNA molecules fold into specific base-paired conformations that contain single-stranded regions, A-form double helices, hairpin loops, internal loops, bulges, junctions, pseudoknots, kissing hairpins, and so forth. These structural motifs are recognized by proteins, other RNAs, and other parts of the same RNA.
Ignacio Tinoco, Jacek Nowakowski
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Abstract RNA molecules fold into specific base-paired conformations that contain single-stranded regions, A-form double helices, hairpin loops, internal loops, bulges, junctions, pseudoknots, kissing hairpins, and so forth. These structural motifs are recognized by proteins, other RNAs, and other parts of the same RNA.
Ignacio Tinoco, Jacek Nowakowski
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Stabilizing RNA by the Sonochemical Formation of RNA Nanospheres [PDF]
Small, 2011 AbstractBiological macromolecules, including DNA, RNA, and proteins, have intrinsic features that make them potential building blocks for the bottom‐up fabrication of nanodevices. Unlike DNA, RNA is a more versatile molecule whose range in the cell is from 21 to thousands of nucleotides and is usually folded into stem and loop structures. RNA is unique
Ulyana Shimanovich +5 more
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RNA stabilization in hyperthermophilic archaea
Annals of the New York Academy of Sciences, 2019AbstractAnalyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA‐guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC‐rich regions are observed for many universal noncoding RNA families ...
Lennart Randau +1 more
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Thermodynamic Studies of RNA Stability
Journal of Biomolecular Structure and Dynamics, 1984Enthalpies and entropies of helix stabilization due to addition of 3' terminal unpaired nucleotides to a CCGG or GGCC core double helix are derived from UV melting studies. The results suggest stacking provides a significant fraction of the free energy of a terminal base pair.
David R. Hickey +3 more
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Chloroplast RNA processing and stability
Photosynthesis Research, 2004Primary chloroplast transcripts are processed in a number of ways, including intron splicing, internal cleavage of polycistronic RNAs, and endonucleolytic or exonucleolytic cleavages at the transcript termini. All chloroplast RNAs are also subject to degradation, although a curious feature of many chloroplast mRNAs is their relative longevity.
David L. Herrin, Jöerg Nickelsen
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Polyamines, ribonucleases, and the stability of RNA
Molecular and Cellular Biochemistry, 1977The polyamines influence the activity of many enzymes involved in the synthesis and degradation of RNA. These organic cations (putrescine, spermidine, spermine) stimulate, for example, many DNA-dependent RNA polymerases and affect both RNA chain elongation and initiation.
P. A. Hieter +3 more
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Stabilization of RNA Encapsulated in Silk
ACS Biomaterials Science & Engineering, 2018The use of mRNA and miRNA as diagnostic parameters and therapeutic agents has drawn wide interest both clinically and in research. However, RNA is a labile molecule, which requires strict storage conditions, often including cold temperatures or dry environments, in order to preserve RNA integrity.
Jiuyang He +6 more
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