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Stability of nucleolar 45-S RNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967Abstract With respect to sedimentation, nucleolar 45-S RNA was stable for 48 h at room temperature in 0.05 M sodium acetate buffer at pH 5.1 and in Tris buffer at pH 9.0 for 2 h. No change in the sedimentation pattern occurred after dialysis, incubation with EDTA or incubation with proteolytic enzymes.
Harris Busch, Ken Higashi
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Regulation of RNA Stability Through RNA Modification
2021As intracellular RNA levels are determined by the balance between RNA synthesis and decay, RNA stability is a critical factor in the quantity of intracellular RNA. Recent advances in epitranscriptomic measuring techniques have shown that RNA modifications, such as methylation and acetylation, affect RNA stability, including those of messenger RNA (mRNA)
Kentaro Kawata, Nobuyoshi Akimitsu
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Stability of the messenger RNA-transfer RNA-ribosome complex
Journal of Molecular Biology, 1968Abstract The thermal stability of the mRNA-aminoacyl-tRNA-ribosome complex and each of its individual components was examined. A temperature-dependent, reversible dissociation of the mRNA-tRNA-ribosome complex has been demonstrated. By analogy with polynucleotide melting curves, the dissociation of the mRNA-tRNA-ribosome complex is considered as a ...
J. Dondon +4 more
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Control of messenger RNA stability
Immunology Today, 1987Gene expression can be controlled at many levels. Changes in the rate of transcription of a gene, the rate of nuclear processing of the transcript (capping, termination, polyadenylation and splicing) and the rate of transport of the processed transc,ipt from the nucleus to the cytoplasm can contribute to changes in the levels of a particular mRNA. Once
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Gene expression regulated by RNA stability
Science, 2020The factor responsible for autoregulation of tubulin RNA stability is ...
Don W. Cleveland, Ofer Shoshani
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1998
The regulation of RNA stability represents one of the key processes determining the level of chloroplast gene expression [1–3]. Several lines of evidence support this idea: 1) Changes in transcription rates alone cannot account for the different transcript levels of plastid genes detected in light versus dark grown higher plants [4, 5].
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The regulation of RNA stability represents one of the key processes determining the level of chloroplast gene expression [1–3]. Several lines of evidence support this idea: 1) Changes in transcription rates alone cannot account for the different transcript levels of plastid genes detected in light versus dark grown higher plants [4, 5].
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Transcriptome-Wide Profiling of RNA Stability
2021Gene expression is controlled at multiple levels, including RNA transcription and turnover. But determining the relative contributions of RNA biogenesis and decay to the steady-state abundance of cellular transcripts remains challenging because conventional transcriptomics approaches do not provide the temporal resolution to derive the kinetic ...
Stefan L Ameres +4 more
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Determinants of messenger RNA stability
Cell, 1987The steady-state levels of functional mRNAs are determined in part by their rates of decay in the cytoplasm. Hence, this process plays an important role in the control of gene expression. Individual mRNA species differ widely with respect to metabolic stability.
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Stability of nuclear RNA in mammalian cells
Journal of Molecular Biology, 1974Abstract The kinetics of entry of [3H]adenosine into ATP, cellular RNA, and nuclear RNA of mouse L cells were determined and analyzed. A molar accumulation curve for RNA was estimated from the specific radioactivities of RNA and ATP; this curve was resolved graphically into stable and unstable components.
Edwin H. McConkey, Bruce P. Brandhorst
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Chapter 4 Poly(A)‐Assisted RNA Decay and Modulators of RNA Stability
2009In Escherichia coli, RNA degradation is orchestrated by the degradosome with the assistance of complementary pathways and regulatory cofactors described in this chapter. They control the stability of each transcript and regulate the expression of many genes involved in environmental adaptation.
Eliane Hajnsdorf, Philippe Régnier
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