A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
eLife, 2020 piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA ...
Kevin I Manage +12 more
doaj +1 more source
Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
core +1 more source
RNA Vaccine: novel approach for cancer treatment [PDF]
, 2011 Cancer is still an unsolved puzzle and a major cause of mortality and morbidity in the world. Today, about one in every thousand people is dying due to cancer. No effective agent has yet been found which can cure cancer in its metastatic stage.
Kanika Bhalla +2 more
core +2 more sources
Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]
, 1993 Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea +4 more
core +1 more source
Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis
Nature Communications, 2018 Most RNA folding studies have been performed under non-physiological conditions of high concentrations (≥10 mM) of Mg2+free, while actual cellular concentrations of Mg2+free are only ~1 mM in a background of greater than 50 mM Mg2+total.
R. Yamagami +3 more
semanticscholar +1 more source
Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences [PDF]
, 2002 The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1.
Bourgeois, Cyril F +4 more
core +3 more sources
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
bioRxiv, 2021 Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA instability and inefficient protein expression.
Kathrin Leppek +20 more
semanticscholar +1 more source
Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability [PDF]
, 2011 The evolutionary benefit of viral genome segmentation is a classical, yet unsolved question in evolutionary biology and RNA genetics. Theoretical studies anticipated that replication of shorter RNA segments could provide a replicative advantage over ...
Arias, Armando +7 more
core +3 more sources
Stabilization of RNA stacking by pseudouridine [PDF]
Nucleic Acids Research, 1995 The effect of the modified nucleoside pseudouridine (psi) on RNA structure was compared with uridine. The extent of base stacking in model RNA oligonucleotides was measured by 1H NMR, UV, and CD spectroscopy. The UV and CD results indicate that the model single-stranded oligoribonucleotides AAUA and AA psi A form stacked structures in solution and the ...
openaire +3 more sources
Regulation of cytoplasmic RNA stability: Lessons from Drosophila
Wiley Interdisciplinary Reviews - RNA, 2018 The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Benjamin P. Towler, S. Newbury
semanticscholar +1 more source