Results 71 to 80 of about 4,719,315 (357)

ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma

Cancer Cell International, 2020
Background Osteosarcoma (OS) is one of the most common malignant bone tumors. Plasmacytoma variant translocation 1 (PVT1) is a well-known oncogenic long noncoding RNA (lncRNA). However, to date, the regulatory mechanism of PVT1 upregulation in OS remains
Shuo Chen, Liwu Zhou, Yang Wang
doaj   +1 more source

Interplay of the RNA Exosome Complex and RNA-Binding Protein Ssd1 in Maintaining Cell Wall Stability in Yeast

Microbiology Spectrum, 2021
Yeast cell wall stability is important for cell division and survival under stress conditions. The expression of cell-wall-related proteins is regulated by several pathways involving RNA-binding proteins and RNases.
Ana Novačić, Nada Šupljika, Nikša Bekavac, Bojan Žunar, Igor Stuparević   +4 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Reference gene selection and RNA preservation protocol in the cat flea, Ctenocephalides felis, for gene expression studies [PDF]

, 2016
This work was supported by a Knowledge Transfer Network BBSRC Industrial Case (#414 BB/L502467/1) studentship in association Zoetis Inc.Peer ...
Baird, John, Bowman, Alan S, Campbell, Ewan M, McIntosh, Catriona H, Woods, Debra J., Zinser, Erich   +5 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Immunostimulating capacities of stabilized RNA molecules [PDF]

European Journal of Immunology, 2004
AbstractSince direct injection of naked mRNA induces an immune response, we tested the capacity of RNA to signal danger. We show here that mRNA molecules that are protected from immediate degradation either through interaction with cationic proteins (trans protection) or through chemical modification of the phosphodiester backbone (phosphorothioate RNA;
Birgit Scheel, Günther Jung, Hans-Georg Rammensee, Jean-Philippe Carralot, Steve Pascolo, Jochen Probst, Hansjörg Schild, Hermann Wagner, Sybilla Braedel   +8 more
openaire   +3 more sources

AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates

npj Metabolic Health and Disease
The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its activity and promote cell ...
William J. Smiles, Ashley J. Ovens, Dingyi Yu, Naomi X. Y. Ling, Andrea C. Poblete Goycoolea, Kaitlin R. Morrison, Emmanuel O. Murphy, Astrid Glaser, Sophie F. Monks O’Byrne, Scott Taylor, Alistair M. Chalk, Carl R. Walkley, Luke M. McAloon, John W. Scott, Bruce E. Kemp, Ashfaqul Hoque, Christopher G. Langendorf, Janni Petersen, Sandra Galic, Jonathan S. Oakhill   +19 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

A Statistical Analysis of RNA Folding Algorithms Through Thermodynamic Parameter Perturbation [PDF]

, 2004
Computational RNA secondary structure prediction is rather well established. However, such prediction algorithms always depend on a large number of experimentally measured parameters.
Bundschuh, R., Layton, D. M.
core   +3 more sources

A Method to Predict the Structure and Stability of RNA/RNA Complexes [PDF]

, 2016
RNA/RNA interactions are essential for genomic RNA dimerization and regulation of gene expression. Intermolecular loop-loop base pairing is a widespread and functionally important tertiary structure motif in RNA machinery. However, computational prediction of intermolecular loop-loop base pairing is challenged by the entropy and free energy calculation
Xiaojun Xu, Xiaojun Xu, Shi-Jie Chen, Shi-Jie Chen   +3 more
openaire   +2 more sources