Results 141 to 150 of about 15,140,513 (376)
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Probing the Structures of Viral RNA Regulatory Elements with SHAPE and Related Methodologies
Frontiers in Microbiology, 2018 Viral RNAs were selected by evolution to possess maximum functionality in a minimal sequence. Depending on the classification of the virus and the type of RNA in question, viral RNAs must alternately be replicated, spliced, transcribed, transported from ...
Jason W. Rausch +3 more
doaj +1 more source
Special Issue: Frontiers in RNA Structure
Molecules, 2020 The frontiers of our knowledge about RNA structure are rapidly moving [...]
Quentin Vicens
doaj +1 more source
Blind prediction of noncanonical RNA structure at atomic accuracy
Science Advances, 2017 We report a new algorithm and a battery of blind challenges for the prediction of complex RNA structures at atomic accuracy. Prediction of RNA structure from nucleotide sequence remains an unsolved grand challenge of biochemistry and requires distinct ...
A. Watkins +5 more
semanticscholar +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
DIMPL: a bioinformatics pipeline for the discovery of structured noncoding RNA motifs in bacteria [PDF]
, 2021 Kenneth I. Brewer +3 more
openalex +1 more source
RNAs everywhere: genome‐wide annotation of structured RNAs
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2006 AbstractStarting with the discovery of microRNAs and the advent of genome‐wide transcriptomics, non‐protein‐coding transcripts have moved from a fringe topic to a central field research in molecular biology. In this contribution we review the state of the art of “computational RNomics”, i.e., the bioinformatics approaches to genome‐wide RNA annotation.
Backofen, Rolf +15 more
openaire +6 more sources
Nature Structural &Molecular Biology, 2016 The B-DNA double helix can dynamically accommodate G-C and A-T base pairs in either Watson–Crick or Hoogsteen configurations. Here, we show that G-C+ (in which + indicates protonation) and A-U Hoogsteen base pairs are strongly disfavored in A-RNA.
Huiqing Zhou +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source