Results 171 to 180 of about 15,140,513 (376)

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

Nature Communications, 2017
The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy, Gustavo M. A. Lima, Ketllyn I. Z. Oliveira, Naiara U. Torres, Fernando V. Maluf, Rafael V. C. Guido, Glaucius Oliva   +6 more
doaj   +1 more source

Prediction of RNA pseudoknots by Monte Carlo simulations

, 2004
In this paper we consider the problem of RNA folding with pseudoknots. We use a graphical representation in which the secondary structures are described by planar diagrams. Pseudoknots are identified as non-planar diagrams.
Orland, H., Vernizzi, G., Zee, A.
core   +1 more source

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

Targeting RNA structures with small molecules [PDF]

, 2022
Jessica L. Childs‐Disney, Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert Batey, Matthew D. Disney   +5 more
openalex   +1 more source

Evolutionary perspectives of telomerase RNA structure and function

RNA Biology, 2016
Telomerase is the eukaryotic solution to the ‘end-replication problem’ of linear chromosomes by synthesising the highly repetitive DNA constituent of telomeres, the nucleoprotein cap that protects chromosome termini.
Joshua D. Podlevsky, Julian J‐L Chen
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations

, 2003
Ab initio RNA secondary structure predictions have long dismissed helices interior to loops, so-called pseudoknots, despite their structural importance.
A. Xayaphoummine, Evers, F. Thalmann, Ferr  -D'Amar  , Giedroc, Gultyaev, H. Isambert, Higgs, Lehnert, Mathews, McCaskill, Mironov, Pan, Pleij, Rivas, Russell, Sclavi, Shirts, T. Bucher, Tinoco, Treiber, Zarrinkar, Zuker   +22 more
core   +3 more sources

Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA polymerase III [PDF]

, 2011
Haruhiko Ehara, Shun‐ichi Sekine, Shigeyuki Yokoyama   +2 more
openalex   +1 more source

Dengue Virus RNA Structure Specialization Facilitates Host Adaptation

PLoS Pathogens, 2015
Many viral pathogens cycle between humans and insects. These viruses must have evolved strategies for rapid adaptation to different host environments. However, the mechanistic basis for the adaptation process remains poorly understood.
Sergio M Villordo, Claudia V Filomatori, I. Sánchez-Vargas, C. Blair, A. Gamarnik   +4 more
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source