Results 121 to 130 of about 3,365,264 (261)
Remnants of the Balbiani body are required for formation of RNA transport granules in Xenopus oocytes. [PDF]
iScience, 2022 Yang C +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
PLoS ONE, 2015 The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation.
Glenn Hauk, Gregory D Bowman
doaj +1 more source
RNA transport and local translation in neurodevelopmental and neurodegenerative disease. [PDF]
Nat Neurosci, 2021 Fernandopulle MS +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A novel family of mammalian transmembrane proteins involved in cholesterol transport
Scientific Reports, 2017 Cholesterol is an essential compound in mammalian cells because it is involved in a wide range of functions, including as a key component of membranes, precursor of important molecules such as hormones, bile acids and vitamin D. The cholesterol transport
Kevin M. Méndez-Acevedo +3 more
doaj +1 more source
RNA transport from transcription to localized translation: a single molecule perspective. [PDF]
RNA Biol, 2021 Basyuk E, Rage F, Bertrand E.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Investigation of RNA-mediated pathogenic pathways in a Drosophila model of expanded repeat disease. [PDF]
, 2010 Expansion of a repeat sequence beyond a pathogenic range has been identified as the cause of a group of neurodegenerative diseases known as the expanded repeat diseases.
van Eyk, Clare Louise
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