Results 101 to 110 of about 531,517 (296)
Retrograde transport pathways utilised by viruses and protein toxins [PDF]
, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord +9 more
core +1 more source
Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
Frontiers in Microbiology, 2015 Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the ...
Wahyu eWulan +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast [PDF]
, 2005 We report that Ypl146cp/Nop53p is associated with pre-60S ribosomal complexes and localized to the nucleolus and nucleoplasm. in cells depleted of Nop53p synthesis of the rRNA components of the 60S ribosomal subunit is severely inhibited, with strikingly
Tollervey, D, Thomson, E
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases [PDF]
, 2018 In eukaryotic cells, transcription and translation are compartmentalized by the nuclear membrane, requiring an active transport of RNA from the nucleus into the cytoplasm.
Robert Bowser +3 more
core +1 more source
Using the yeast three-hybrid system to identify proteins that interact with a phloem-mobile mRNA
Frontiers in Plant Science, 2012 Heterografting and RNA transport experiments have demonstrated the long-distance mobility of StBEL5 RNA, its role in controlling tuber formation, and the function of the 503-nt 3´ untranslated region (UTR) of the RNA in mediating transport.
Sung Ki eCho +3 more
doaj +1 more source
RNA Transport to the Vegetal Cortex ofXenopusOocytes
Developmental Biology, 1996 Xcat-2 RNA, a component of the germ plasm in Xenopus, localizes with the mitochondrial cloud material to the vegetal cortex in stage II oocytes. Vg1 RNA also localizes to the vegetal cortex, but later in stage III/IV oocytes, using a microtubule dependent pathway.
Zhou, Yi, King, Mary Lou
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Regulation of Na+/K+ ATPase transport velocity by RNA editing.
PLoS Biology, 2010 Because firing properties and metabolic rates vary widely, neurons require different transport rates from their Na(+)/K(+) pumps in order to maintain ion homeostasis.
Claudia Colina +4 more
doaj +1 more source