Results 71 to 80 of about 3,365,264 (261)

Rev-free HIV-1 gene delivery system for targeting Rev-RRE-Crm1 nucleocytoplasmic RNA transport pathway.

PLoS ONE, 2011
The use of RNA transport elements from different viruses can provide novel attributes to HIV-1-based gene delivery systems such as improved safety or Rev independence.
Narasimhachar Srinivasakumar
doaj   +1 more source

Cell-to-Cell Movement of Potexviruses: Evidence for a Ribonucleoprotein Complex Involving the Coat Protein and First Triple Gene Block Protein

Molecular Plant-Microbe Interactions, 2000
The triple gene block proteins (TGBp1-3) and coat protein (CP) of potexviruses are required for cell-to-cell movement. Separate models have been proposed for inter-cellular movement of two of these viruses, transport of intact virions, or a ...
Tony J. Lough, Natalie E. Netzler, Sarah J. Emerson, Paul Sutherland, Fiona Carr, David L. Beck, William J. Lucas, Richard L. S. Forster   +7 more
doaj   +1 more source

Systemic Long-Distance Signaling and Communication Between Rootstock and Scion in Grafted Vegetables

Frontiers in Plant Science, 2020
Grafting is widely used in fruit, vegetable, and flower propagation to improve biotic and abiotic stress resistance, yield, and quality. At present, the systemic changes caused by grafting, as well as the mechanisms and effects of long-distance signal ...
Xiaohong Lu, Wenqian Liu, Tao Wang, Jiali Zhang, Xiaojun Li, Wenna Zhang   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

, 2012
The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest TA family, little is known about
Cook, Gregory M., Mackay, Joel, Cursons, Raymond T., Duyvestyn, Johanna Maria, Mckenzie, Joanna L., Smith, Tony C., Bendak, Katerina, Smith, Tony, Cursons, R. A.Y., Mackay, Joel P., Arcus, Vickery L., Duyvestyn, Johanna M., McKenzie, Joanna Leigh, https://orcid.org/   +13 more
core   +1 more source

The mutual interaction of glycolytic enzymes and RNA in post-transcriptional regulation

, 2022
Wegener M, Dietz K-J. The mutual interaction of glycolytic enzymes and RNA in post-transcriptional regulation. RNA . 2022.About three decades ago, researchers suggested that metabolic enzymes participate in cellular processes that are unrelated to their ...
Dietz, Karl-Josef, Karl-Josef Dietz, Wegener, Melanie, Melanie Wegener   +3 more
core   +1 more source

Ammonium sulfate denatures transport medium less dependent on guanidinium isothiocyanate and enables SARS-CoV-2 RNA and antigen detection compatibility

Frontiers in Microbiology
IntroductionRapid identification of infected individuals through viral RNA or antigen detection followed by effective personal isolation is usually the most effective way to prevent the spread of a newly emerging virus.
Ge Liu, Jiapeng Xu, Yuanyuan Huang, Wei Ye, Jieyu Li, Ran Yan, Qiting Luo, Xinrui Zhou, Yingna Cai, Hanfang Jiang, Xiujing Lu, Kai Zheng, Zhendan He, Qinchang Zhu, Qinchang Zhu   +14 more
doaj   +1 more source

RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs

Retrovirology, 2006
Studies of retroviral mRNA export identified two distinct RNA export elements utilizing conserved eukaryotic mRNA export mechanism(s), namely the Constitutive Transport Element (CTE) and the RNA Transport Element (RTE). Although RTE and CTE are potent in
Michalowski Daniel, von Gegerfelt Agneta, Zolotukhin Andrei S, Jalah Rashmi, Rosati Margherita, Alicea Candido, Bear Jenifer, Smulevitch Sergey, Moroni Christoph, Pavlakis George N, Felber Barbara K   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source