Results 71 to 80 of about 3,158,683 (345)

RNA Virus Populations as Quasispecies [PDF]

, 1992
RNA virus mutation frequencies generally approach maximum tolerable levels, and create complex indeterminate quasispecies populations in infected hosts. This usually favors extreme rates of evolution, although periods of relative stasis or equilibrium, punctuated by rapid change may also occur (as for other life forms).
J C de la Torre, David A. Steinhauer, John J. Holland   +2 more
openaire   +3 more sources

Bovine Leukemia Virus: An Exogenous RNA Oncogenic Virus? [PDF]

Proceedings of the National Academy of Sciences, 1976
Short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of RNA oncogenic viruses. These particles, tentatively called bovine leukemia virus (BLV), have a high molecular weight RNA-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions.
Kettmann, Richard, Portetelle, Daniel, Mammerickx, Marc, Cleuter, Yvette, Dekegel, Daniel, Galoux, Michel, Ghysdael, Jacques, Burny, Arsène, Chantrenne, Hubert   +8 more
openaire   +4 more sources

Multiple Regions of Kaposi’s Sarcoma-Associated Herpesvirus ORF59 RNA are Required for Its Expression Mediated by Viral ORF57 and Cellular RBM15

Viruses, 2015
KSHV ORF57 (MTA) promotes RNA stability of ORF59, a viral DNA polymerase processivity factor. Here, we show that the integrity of both ORF59 RNA ends is necessary for ORF57-mediated ORF59 expression and deletion of both 5’ and 3’ regions, or one end ...
Maria Julia Massimelli, Vladimir Majerciak, Jeong-Gu Kang, David J. Liewehr, Seth M. Steinberg, Zhi-Ming Zheng   +5 more
doaj   +1 more source

COVID-19: An up-to-date review – from morphology to pathogenesis

Indian Journal of Pathology and Microbiology, 2020
The entire world is under a devastating pandemic caused by COVID-19 with a high mortality rate. Knowledge of the viral structure, factors that help in its progression and spread, pathological findings, diagnostic methods and, treatment modalities helps ...
Amanjit Bal, Ranjan Agrawal, Pradeep Vaideeswar, Sudheer Arava, Amita Jain   +4 more
doaj   +1 more source

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2009
Induced pluripotent stem cells (iPSC) have been generated from somatic cells by introducing reprogramming factors. Integration of foreign genes into the host genome is a technical hurdle for the clinical application. Here, we show that Sendai virus (SeV),
N. Fusaki, H. Ban, Akiyo Nishiyama, Koichi Saeki, M. Hasegawa   +4 more
semanticscholar   +1 more source

VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses

Microbiome, 2021
Viruses are a significant player in many biosphere and human ecosystems, but most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to the lack of universal gene markers, database representatives, and insufficiently advanced
Jiarong Guo, B. Bolduc, A. Zayed, A. Varsani, Guillermo Domínguez-Huerta, Tom O. Delmont, Akbar Adjie Pratama, M. C. Gazitúa, D. Vik, M. Sullivan, S. Roux   +10 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Oncogenes and RNA splicing of human tumor viruses

Emerging Microbes and Infections, 2014
Approximately 10.8% of human cancers are associated with infection by an oncogenic virus. These viruses include human papillomavirus (HPV), Epstein–Barr virus (EBV), Merkel cell polyomavirus (MCV), human T-cell leukemia virus 1 (HTLV-1), Kaposi's sarcoma-
Masahiko Ajiro, Zhi-Ming Zheng
doaj   +1 more source

IVA: accurate de novo assembly of RNA virus genomes

Bioinform., 2015
Motivation: An accurate genome assembly from short read sequencing data is critical for downstream analysis, for example allowing investigation of variants within a sequenced population.
Martin Hunt, Astrid Gall, S. Ong, Jacqui Brener, B. Ferns, Philip Goulder, Eleni Nastouli, Jacqueline A. Keane, P. Kellam, Thomas D. Otto   +9 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source