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A novel T cell evasion mechanism in persistent RNA virus infection.

open access: green, 2014
Jack T. Stapleton   +7 more
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Sensing RNA virus infections

Nature Chemical Biology, 2007
RIG-I is an RNA helicase that senses viral infections and triggers innate and adaptive immune mechanisms. Recent studies have identified RNAs bearing 5′-triphosphates as ligands of RIG-I and have suggested a mechanism for how RIG-I distinguishes viral RNA from host RNA.
Christopher F Basler   +1 more
openaire   +1 more source

Emerging Roles of tRNAs in RNA Virus Infections

Trends in Biochemical Sciences, 2020
Viruses rely on the host cell translation machinery for efficient synthesis of their own proteins. Emerging evidence highlights different roles for host transfer RNAs (tRNAs) in the process of virus replication. For instance, different RNA viruses manipulate host tRNA pools to favor viral protein translation. Interestingly, specific host tRNAs are used
Alexandre Nunes   +5 more
openaire   +3 more sources

Infectivity studies of bromegrass mosaic virus RNA

Virology, 1965
Abstract The infectivity of bromegrass mosaic virus (BMV) RNA has been investigated. The infectivity per unit weight of unfractionated RNA was approximately one-third that of an equivalent weight of RNA in the virus. No significant loss of infectivity occurred during 70 hours of incubation at 30°.
L E, Bockstahler, P, Kaesberg
openaire   +2 more sources

RVvictor: Virus RNA-directed molecular interactions for RNA virus infection

Computers in Biology and Medicine
RNA viruses are major human pathogens that cause seasonal epidemics and occasional pandemic outbreaks. Due to the nature of their RNA genomes, it is anticipated that virus's RNA interacts with host protein (INTPRO), messenger RNA (INTmRNA), and non-coding RNA (INTncRNA) to perform their particular functions during their transcription and replication ...
Kuerbannisha Amahong   +7 more
openaire   +2 more sources

RNA Silencing in Productive Virus Infections

Annual Review of Phytopathology, 2005
RNA silencing can reduce the expression of specific genes through posttranscriptional gene silencing, the microRNA pathway, and also through transcriptional gene silencing. Posttranscriptional gene silencing also acts as an antivirus mechanism. By suppressing this antivirus defense mechanism, viruses affect all three silencing pathways in addition to ...
openaire   +2 more sources

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