Results 301 to 310 of about 447,697 (355)

RNA interference acts as a natural antiviral response to O'nyong-nyong virus ( Alphavirus ; Togaviridae) infection of Anopheles gambiae

, 2004
Kimberly M. Keene, Brian D. Foy, Irma Sánchez-Vargas, Barry J. Beaty, Carol D. Blair, Ken E. Olson   +5 more
openalex   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

A One Health Approach to Investigating Cache Valley Virus, Arkansas, USA, July 2023¹. [PDF]

Emerg Infect Dis
Carpenter A, Kojima N, Dulski TM, Calvert AE, Burkhalter KL, Ballard JR, Blount K, Fagre A, Thrasher E, Lazenby K, Hedges S, Long A, Miazgowicz K, Wood E, Owens P, Connelly CR, Gould CV, Staples JE, Rothfeldt L, Martin SW, Burke J.   +20 more
europepmc   +1 more source

The C-terminal 33 amino acids of the cucumber mosaic virus 3a protein affect virus movement, RNA binding and inhibition of infection and translation

, 2004
Sang Hyon Kim, Natalia O. Kalinina, И. А. Андреев, Eugene V. Ryabov, Alexander G. Fitzgerald, Michael Taliansky, Peter Palukaitis   +6 more
openalex   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Viral infection and its impact on fertility, medically assisted reproduction and early pregnancy - a narrative review. [PDF]

Reprod Biol Endocrinol
Piotr L, Aleksandra Z, Adam C, Katarzyna OW, Damian W, Cezary W, Rafał K.   +6 more
europepmc   +1 more source

Short Interfering RNA-Mediated Inhibition of Herpes Simplex Virus Type 1 Gene Expression and Function during Infection of Human Keratinocytes

, 2004
Prakash Bhuyan, Katalin Karikó, John Capodici, John M. Lubinski, Lauren M. Hook, Harvey M. Friedman, Drew Weissman   +6 more
openalex   +1 more source

DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics

Advanced Science, EarlyView.
A molecular computing approach is presented with weighted signal amplification. Polymerase‐mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly.
Hongyang Zhao, Yumin Yan, Linghao Zhang, Xin Li, Lan Jia, Liang Ma, Xin Su   +6 more
wiley   +1 more source

Hepatitis E Virus in the Role of an Emerging Food-Borne Pathogen. [PDF]

Microorganisms
Pavlova A, Kocikova B, Dolinska MU, Jackova A.   +3 more
europepmc   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source