Results 231 to 240 of about 2,156,375 (387)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

CIRCpedia v3: an interactive database for circular RNA characterization and functional exploration. [PDF]

Nucleic Acids Res
Zhai SN, Zhang YY, Chen MH, Fu ZC, Chen LL, Ma XK, Yang L.   +6 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Editorial: RNA at a breaking point? Cytoplasmic cleavage and other post-transcriptional RNA processing in neurodevelopment and disease

Frontiers in Molecular Neuroscience, 2023
Monika Piwecka, Raphaelle Luisier, Raphaelle Luisier, Catia Andreassi   +3 more
doaj   +1 more source

Phosphorylation event changes the RNA binding mode of EZH2 disordered segment. [PDF]

Protein Sci
Szabó B, Micsonai A, Kardos J, Tantos Á.   +3 more
europepmc   +1 more source

Development of Multiplexed Reverse-Transcription Loop-Mediated Isothermal Amplification for Detection of SARS-CoV-2 and Influenza Viral RNA

, 2021
Yinhua Zhang, Nathan A. Tanner
openalex   +1 more source

Structure-Guided Engineering of the Homodimeric Mango-IV Fluorescence Turn-on Aptamer Yields an RNA FRET Pair [PDF]

, 2020
Robert J. Trachman, Razvan Cojocaru, Di Wu, Grzegorz Piszczek, Michaël Ryckelynck, Peter J. Unrau, A.R. Ferré-D′Amaré   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

siRNAs, tRNAs, and rRNAs in Osteoarthritis: Biological Functions and Therapeutic Opportunities

Biologics: Targets & Therapy
Mina Wang,1,* Yidan Dai,1,* Xiaobo Ge,1,* Libin Zheng,1,2 Miaoxin Zhai,3 Wenshan Li,1,2 Guannan Liu,1 Xiaoyu Cheng,1 Jiangyan Wei,1 Xin Yang,1 Lu Liu,1 Huilin Liu,1 Jingqing Sun,1 Bin Li,1 Fang Yuan1 1Department of Acupuncture and
Wang M, Dai Y, Ge X, Zheng L, Zhai M, Li W, Liu G, Cheng X, Wei J, Yang X, Liu L, Liu H, Sun J, Li B, Yuan F   +14 more
doaj  

R-loops and small RNA regulatory interactions: mechanisms and clinical perspectives. [PDF]

Front Cell Dev Biol
Wang SY, Liu YN, Zhao SQ, Liu W, Hu JL, Yang F, Wang S.   +6 more
europepmc   +1 more source