Results 171 to 180 of about 290,253 (274)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

An improved cytological assay for R-loop detection in Saccharomyces cerevisiae utilizing a catalytically inactive RNase H. [PDF]

G3 (Bethesda)
Sanders J, Hakeem Z, Schwacha A.
europepmc   +1 more source

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

, 2014
Roberta Costi, Mathieu Métifiot, Suhman Chung, Giuliana Cuzzucoli Crucitti, Kasthuraiah Maddali, Luca Pescatori, Antonella Messore, Valentina Noemi Madia, Giovanni Pupo, Luigi Scipione, Silvano Tortorella, Francesco Saverio Di Leva, Sandro Cosconati, Luciana Marinelli, Ettore Novellino, Stuart F.J. Le Grice, Angela Corona, Yves Pommier, Christophe Marchand, Roberto Di Santo   +19 more
openalex   +1 more source

Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline [PDF]

, 2019
Ross D. Overacker, Somdev Banerjee, George F. Neuhaus, Selena Milicevic Sephton, Alexander Herrmann, James A. Strother, Ruth Brack‐Werner, Paul R. Blakemore, Sandra Loesgen   +8 more
openalex   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Consecutive 5′- and 3′-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

, 2020
Sven Epple, Cameron Thorpe, Ysobel R. Baker, Afaf H. El‐Sagheer, Tom Brown   +4 more
openalex   +2 more sources

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

, 2010
Muriel Billamboz, Fabrice Bailly, Cédric Lion, Christina Calmels, Marie‐Line Andréola, Myriam Witvrouw, Frauke Christ, Zeger Debyser, Laura De Luca, Alba Chimirri, Philippe Cotelle   +10 more
openalex   +2 more sources

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

The Dual Role of Histidine as General Base and Recruiter of a Third Metal Ion in HIV-1 RNase H

, 2019
Simon Dürr, Olga Bohuszewicz, Reynier Suardíaz, Pablo G. Jambrina, Christine Peter, Yihan Shao, Edina Rosta   +6 more
openalex   +1 more source