Quantitative analysis of miRNAs using SplintR ligase-mediated ligation of complementary-pairing probes enhanced by RNase H (SPLICER)-qPCR. [PDF]
Mol Ther Nucleic Acids, 2023 Qin X +7 more
europepmc +1 more source
Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]
, 1998 Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
core
Molecular cloning of a ribonuclease H (RNase HI) gene from an extreme thermophileThermus thermophilusHB8: a thermostable RNase H can functionally replace theEscherichia colienzymein vivo [PDF]
, 1991 Mitsuhiro Itaya, Kanae Kondo
openalex +1 more source
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Advanced Materials, EarlyView.Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang +4 more
wiley +1 more source
Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. [PDF]
Acta Crystallogr D Struct Biol, 2022 Preussner M +6 more
europepmc +1 more source
Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H [PDF]
, 1992 Alice Telesnitsky +2 more
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Nanoinjection Platform for Drug Delivery in Breast Cancer Therapeutics
Advanced Materials Interfaces, EarlyView.A schematic shows Nanoarchaeosomes loaded with doxorubicin (NAD) delivered via silicon nanotubes (SiNTs) into MCF‐7 cells, triggering apoptosis and necrosis. Released doxorubicin generates ROS, disrupts mitochondria, and intercalates DNA. This dual‐action nanoinjection enhances cytotoxicity and improves breast cancer therapy efficacy.
Kaviya Vijayalakshmi Babunagappan +8 more
wiley +1 more source
Expression of thermostable MMLV reverse transcriptase in Escherichia coli by directed mutation
AMB ExpressThe functionality of Moloney murine leukemia virus reverse transcriptase (MMLV RT) will increase with the improvement of its solubility and thermal stability.
Marzieh Divbandi +4 more
doaj +1 more source
RNase H is an exo- and endoribonuclease with asymmetric directionality, depending on the binding mode to the structural variants of RNA:DNA hybrids. [PDF]
Nucleic Acids Res, 2022 Lee H +6 more
europepmc +1 more source
Eukaryotic RNAse H shares a conserved domain with caulimovirus proteins that facilitate translation of polycistronic RNA [PDF]
, 1994 Arcady Mushegian +2 more
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