Results 251 to 260 of about 315,883 (294)

A Nonviral Neo‐Nucleocapsid for Cell‐Specific RNA Delivery Developed by Pseudo‐Cyclic Peptide Grafting and Directed Evolution

Angewandte Chemie, EarlyView.
Nonviral neo‐nucleocapsids developed from a repurposed bacterial protein cage, and macrocyclic peptide pharmacophores via protein‐protein ligation, bacteria‐based directed evolution, lasso‐grafting, and mammalian cell‐based directed evolution enabled cell specific RNA delivery.
Daiki Kanayama, Naohiro Terasaka, Kazuki Kato, Sae Okazaki, Hiroaki Suga   +4 more
wiley   +2 more sources

Discovery of <i>N</i>-Hydroxypyridinedione-Based Inhibitors of HBV RNase H: Design, Synthesis, and Extended SAR Studies. [PDF]

Int J Mol Sci
Chotzalli D, Pardali V, Walden HM, Perivolaris D, Moianos D, Makri M, Drakopoulos A, Giannakopoulou E, Tajwar R, Woodson ME, Tavis JE, Zoidis G.   +11 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Playing with Structural Parameters in the Design of Ruthenium(II)-<i>p</i>-Cymene Complexes as Potential Antibacterial Agents. [PDF]

Inorg Chem
Giacomazzo GE, Ceccherini V, Vitali V, Conti L, Vaccaro F, Coscione F, Perrin E, Fondi M, Massai L, Giorgi C, Messori L.   +10 more
europepmc   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. [PDF]

Nat Commun
Liu Y, Avathan Veettil AK, Gasper R, Jiang M, Wagner L, Hastürk O, Wu P.   +6 more
europepmc   +1 more source

Recent advances in hydrogel-based therapeutics for lung cancer. [PDF]

RSC Adv
Sun K, Qiu J, Wang Y, Han F, Song H, Wu T, Wang Y, Jiao W.   +7 more
europepmc   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +1 more source

Protocol for evaluating RNA-protein associations in mammalian cells with RIP-seq and RIP-qPCR. [PDF]

STAR Protoc
Trotman JB, Li S, Eberhard QE, Zhang Z, Calabrese JM.   +4 more
europepmc   +1 more source

Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH. [PDF]

mSphere
Prophete MD, Mabel A, Bowman P, Salvail H.   +3 more
europepmc   +1 more source