Results 91 to 100 of about 23,526 (215)

Neuroinflammation‐Associated Optic Structural–Functional Degeneration in Early Diabetic Optic Neuropathy

Journal of Diabetes, Volume 18, Issue 3, March 2026.
OCT imaging assessments and visual tests, which were validated by pyroptosis of retinal ganglion cells (RGC) and upregulation of NLRP3 and GSDMD expression, established an early structure‐function‐pathology diabetic optic neuropathy (DON) model in high glucose & obesity mice. Early retinal nerve fiber layer (RNFL)/total retinal thickness (TRT) thinning
Jingyuan Zhu, Jinyuan Wang, Haihan Zhang, Mingyang Wang   +3 more
wiley   +1 more source

A Novel N‐Terminal PRPF6 Variant in Autosomal Dominant Retinitis Pigmentosa

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This report identifies the first N‐terminal PRPF6 variant (c.514C>T) as a cause of autosomal dominant Retinitis Pigmentosa. This novel variant is associated with progressive peripheral vision loss but notably preserved central visual acuity, suggesting a distinct phenotypic expression compared to C‐terminal variants.
Na Li, Yalong Dang
wiley   +1 more source

A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

, 2018
Purpose: To develop a deep learning approach to de-noise optical coherence tomography (OCT) B-scans of the optic nerve head (ONH). Methods: Volume scans consisting of 97 horizontal B-scans were acquired through the center of the ONH using a commercial ...
Aung, Tin, Devalla, Sripad Krishna, Girard, Michael J. A., Perera, Shamira, Pham, Tan Hung, Schmetterer, Leopold, Subramanian, Giridhar, Thiery, Alexandre H., Tun, Tin A., Wang, Xiaofei   +9 more
core   +1 more source

An Artificial Intelligence Enabled System for Retinal Nerve Fiber Layer Thickness Damage Severity Staging

Ophthalmology Science
Purpose: To develop an objective glaucoma damage severity classification system based on OCT-derived retinal nerve fiber layer (RNFL) thickness measurements.
Siamak Yousefi, PhD, Xiaoqin Huang, PhD, Asma Poursoroush, MSc, Julek Majoor, PhD, Hans Lemij, MD, Koen Vermeer, PhD, Tobias Elze, PhD, Mengyu Wang, PhD, Kouros Nouri-Mahdavi, MD, MPH, Vahid Mohammadzadeh, MD, Paolo Brusini, MD, Chris Johnson, PhD   +11 more
doaj   +1 more source

Ability of the optical coherence tomography parameters to identify retinal nerve fibre layer defect in Indian eyes with mild glaucoma

AJO International
Purpose: To compare the diagnostic ability of thickness, deviation and clock-hour map of spectral domain optical coherence tomography (OCT) to detect retinal nerve fibre layer (RNFL) defect in mild glaucoma. Design: Cross sectional study.
Flonny Sunny, Premanand Chandran, Liji Joy, Ganesh V Raman   +3 more
doaj   +1 more source

Retinal Nerve Fibre Layer Thinning in Patients with Thalassaemia, Iron Deficiency Anaemia, and Anaemia of Chronic Diseases

Journal of Ophthalmology, 2020
Purpose. Retinal nerve fibre layer (RNFL) is a sensitive structure, which is affected by anaemia due to hypoxia. A timely detection of RNFL thinning may aid preventing devastating complications.
Suhana Datta, Krishnapada Baidya, Madhumita Banerjee, Somnath Mahapatra, Sudeb Mukherjee   +4 more
doaj   +1 more source

Age and axial length on peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography in nonglaucomatous Taiwanese participants.

PLoS ONE, 2017
PurposeThis study investigates the influence of age and axial length (AL) on the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by optical coherence tomography (OCT).MethodsHealthy patients visiting an eye clinic at a county ...
Pai Huei Peng, Sheng Yao Hsu, Wei Shin Wang, Mei Lan Ko   +3 more
doaj   +1 more source

Analysis of Ganglion Cell Complex and Retinal Nerve Fiber Layer Thickness in Glaucoma Diagnosis

Acta Clinica Croatica, 2017
The aim was to compare retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses in patients with primary open angle glaucoma (POAG), ocular hypertension (OH) and healthy subjects, and to investigate the role of GCC parameters in ...
Sania Vidas, Smiljka Popović-Suić, Katia Novak Lauš, Sonja Jandroković, Martina Tomić, Tomislav Jukić, Miro Kalauz   +6 more
doaj   +1 more source

Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects

Clinical Ophthalmology
Andrew Tirsi,1,2 Joby Tsai,3 Aaron Abizadeh,2 Danielle Kacaj,4 Oksana Procyk,1 Vasiliki Gliagias,2 Nicholas Leung,2 Hanwen Yang,2 Sung Chul Park,1,2 Celso Tello1,2 1Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital/Northwell Health ...
Tirsi A, Tsai J, Abizadeh A, Kacaj D, Procyk O, Gliagias V, Leung N, Yang H, Park SC, Tello C   +9 more
doaj  

Peripapillary retinal nerve fiber layer thickness in normal iranian children measured with optical coherence tomography

Journal of Ophthalmic & Vision Research, 2018
Purpose: This study aimed to measure the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT) in normal Iranian children aged below 18 years.
Yadollah Eslami, Zakieh Vahedian, Sasan Moghimi, Fatemeh Bazvand, Haniyeh Salari, Mojtaba Shahabinejad, Afsaneh Malekpoor, Ghasem Fakhraie   +7 more
doaj   +1 more source