Results 61 to 70 of about 46,024 (262)
Brain SciencesDrug-resistant epilepsy (DRE) is often treated with surgery or neuromodulation. Specifically, responsive neurostimulation (RNS) is a widely used therapy that is programmed to detect abnormal brain activity and intervene with tailored stimulation. Despite
Pegah Askari +5 more
doaj +1 more source
Single‐Molecule Characterization of Bacterial Factor‐Dependent Transcription Activation by Rob
Advanced Science, EarlyView.Factor‐dependent transcription activation is crucial and involves complex interactions between transcription factors, RNA polymerase, and promoter DNA. Using single‐molecule assays, we show that Rob prebinds RNAP to facilitate promoter search and enhances DNA unwinding and promoter escape.
Yuqiong Zhang +7 more
wiley +1 more source
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Nordic Journal of Nursing ResearchRegistered nurses’ (RNs’) perceptions and understanding of the health problems and care needs of patients with chronic obstructive pulmonary disease (COPD) play a crucial role in the quality and continuity of care.
Ruth Øfsti +3 more
doaj +1 more source
Advanced Science, EarlyView.To accelerate the inverse design of heterostructured metal matrix composites, a closed‐loop scientific machine learning framework integrates continual learning prediction with NSGA‐II‐PMCP optimization. The framework maps microstructural descriptors to strength, toughness, and modulus, expands high‐quality Pareto solutions, and guides experimentally ...
Zhiyan Zhong +11 more
wiley +1 more source
A Review of CP-ABE Access Control Schemes In Fog Computing
تحلیل مدارها، داده ها و سامانه هاFog computing with cloud computing is useful for real-time processing in the IoT ecosystem. Fog computing can be used to outsource and lighten the computations of the end nodes because it is closer to the end nodes and has higher processing and ...
Mohammad Ali Alizadeh +2 more
doaj
Advanced Science, EarlyView.A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan +9 more
wiley +1 more source
Epilepsy & Behavior ReportsResponsive neurostimulation (RNS) is a valuable tool in the diagnosis and treatment of medication refractory epilepsy (MRE) and provides clinicians with better insights into patients’ seizure patterns. In this case illustration, we present a patient with
Hael F. Abdulrazeq +6 more
doaj +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Transcriptional regulation of subclass 5b fimbriae
BMC Microbiology, 2008 Background Enterotoxigenic Escherichia coli (ETEC) is a major cause of infant and child mortality in developing countries. This enteric pathogen causes profuse watery diarrhea by elaborating one or more enterotoxins that intoxicate eukaryotic cells and ...
Munson George P +2 more
doaj +1 more source