Results 31 to 40 of about 32,825 (259)
JAMA, 2003 Carly Simon is singing from my car radio, reifying her old grief: Suffering was the only thing made me feel I was alive. Thought that’s just how much it cost to survive in this world. And, knowing how sorrow loves to inhabit the body, how it runs like liquid to the void, I’m nodding in agreement when three young boys swagger across the road, daring me ...
openaire +1 more source
The many roads to cross-presentation [PDF]
The Journal of Experimental Medicine, 2005 Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system ...
Groothuis, Tom A.M., Neefjes, Jacques
openaire +2 more sources
A New Form of Train Detection as a Solution to Improve Level Crossing Closing Time
Sensors, 2023 The critical points on the rail and road network are their intersections, i.e., level crossings. During a train crossing, car traffic is stopped. This reduces the fluidity of traffic on the road and, consequently, can cause congestion.
Michał Zawodny +3 more
doaj +1 more source
Wildlife Society Bulletin, 2013 In the Unicoi Mountains of southwestern North Carolina, USA, a 2 lane scenic byway created a barrier to dispersal for the federally endangered Carolina northern flying squirrel (Glaucomys sabrinus coloratus). Unable to glide across the road, squirrels in
Christine A. Kelly +2 more
doaj +1 more source
Frontiers in Psychology, 2020 Pedestrians are one of the most vulnerable groups at the roadside, furthermore, previous research has demonstrated perceptual-motor limitations in individuals with DCD which may put these individuals at even more at risk in the context of road crossing ...
Kate Wilmut, Catherine Purcell
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
How Effective Is Road Mitigation at Reducing Road-Kill? A Meta-Analysis. [PDF]
PLoS ONE, 2016 Road traffic kills hundreds of millions of animals every year, posing a critical threat to the populations of many species. To address this problem there are more than forty types of road mitigation measures available that aim to reduce wildlife ...
Trina Rytwinski +7 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Effectiveness of wildlife guards at access roads
Wildlife Society Bulletin, 2013 The reconstruction of 90.6 km of U.S. Highway 93 from Evaro to Polson, Montana, USA, includes 41 wildlife crossing structures and 13.4 km of road with wildlife fencing. These measures are aimed at reducing wildlife–vehicle collisions and increasing human
Tiffany D. H. Allen +2 more
doaj +1 more source