Results 71 to 80 of about 1,233,729 (288)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Vulnerable Road Users: Characteristics of Pedestrians
Journal of Road Safety, 2012 Pedestrians are vulnerable road users and comprise the largest single road user group. Walking is a major form of transport in urban areas and crossing a road is a key element in a journey on foot. A pedestrian network is part of the transport system and
Zoran Bakovic
doaj
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Improving pedestrian facilities at signalised crossings
, 2013 Traffic signal control systems are usually designed to maximise vehicle capacity and minimise vehicle delay with the needs of pedestrians considered separately as necessary.
Hassan, Sitti Asmah
core +1 more source
Road Traffic Fatalities in Malawi: The Role of Pedestrian Behaviour Factors
Journal of Road Safety, 2019 Pedestrian behaviour is one of the major contributors to road fatalities. The negative binomial regression model was found to better agree with road fatality data, and this study used this model to assess the influence of pedestrian behaviour factors on ...
Gibson Mpokonyoka Ngwira +2 more
doaj +1 more source
Walk or wait?: An empirical analysis of street crossing decisions [PDF]
We examine the behaviour of pedestrians wishing to cross a stream of trasffic at signalized intersections. We model each padestrian as making a desccrete crossing choice by comparing the gaps between vehicles in traffic to an individual-specific ...
Charles F. Manski +2 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Methodological approaches to determining the cost of maintaining border crossing points for road transport [PDF]
Дороги і мостиIntroduction. The article examines the methodology for determining the cost of services for maintaining border crossing points for road transport. The research highlights the importance of establishing effective resource needs to ensure the uninterrupted
Anatolii Tsynka +4 more
doaj +1 more source
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1998 No Abstract.
openaire +2 more sources