Results 41 to 50 of about 32,443 (259)

The many roads to cross-presentation [PDF]

The Journal of Experimental Medicine, 2005
Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system ...
Groothuis, Tom A.M., Neefjes, Jacques
openaire   +2 more sources

A New Form of Train Detection as a Solution to Improve Level Crossing Closing Time

Sensors, 2023
The critical points on the rail and road network are their intersections, i.e., level crossings. During a train crossing, car traffic is stopped. This reduces the fluidity of traffic on the road and, consequently, can cause congestion.
Michał Zawodny, Maciej Kruszyna, Wojciech Kazimierz Szczepanek, Mariusz Korzeń   +3 more
doaj   +1 more source

Crossing structures reconnect federally endangered flying squirrel populations divided for 20 years by road barrier

Wildlife Society Bulletin, 2013
In the Unicoi Mountains of southwestern North Carolina, USA, a 2 lane scenic byway created a barrier to dispersal for the federally endangered Carolina northern flying squirrel (Glaucomys sabrinus coloratus). Unable to glide across the road, squirrels in
Christine A. Kelly, Corinne A. Diggins, Andrew J. Lawrence   +2 more
doaj   +1 more source

The Lived Experience of Crossing the Road When You Have Developmental Coordination Disorder (DCD): The Perspectives of Parents of Children With DCD and Adults With DCD

Frontiers in Psychology, 2020
Pedestrians are one of the most vulnerable groups at the roadside, furthermore, previous research has demonstrated perceptual-motor limitations in individuals with DCD which may put these individuals at even more at risk in the context of road crossing ...
Kate Wilmut, Catherine Purcell
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effectiveness of wildlife guards at access roads

Wildlife Society Bulletin, 2013
The reconstruction of 90.6 km of U.S. Highway 93 from Evaro to Polson, Montana, USA, includes 41 wildlife crossing structures and 13.4 km of road with wildlife fencing. These measures are aimed at reducing wildlife–vehicle collisions and increasing human
Tiffany D. H. Allen, Marcel P. Huijser, David W. Willey   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

How Effective Is Road Mitigation at Reducing Road-Kill? A Meta-Analysis. [PDF]

PLoS ONE, 2016
Road traffic kills hundreds of millions of animals every year, posing a critical threat to the populations of many species. To address this problem there are more than forty types of road mitigation measures available that aim to reduce wildlife ...
Trina Rytwinski, Kylie Soanes, Jochen A G Jaeger, Lenore Fahrig, C Scott Findlay, Jeff Houlahan, Rodney van der Ree, Edgar A van der Grift   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source