Results 61 to 70 of about 3,805,880 (279)

Qualitative evaluation and optimization of forest road network to minimize total costs and environmental impacts

open access: yesiForest - Biogeosciences and Forestry, 2012
An efficient and low-cost transportation network is necessary for sustainable management. Roading and log skidding are the most expensive and destructive operations in forest environment, unless carefully planned and evaluated.
Hayati E, Majnounian B, Abdi E
doaj   +1 more source

The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021

open access: yes
BACKGROUND: Fractures related to osteoporosis and low bone mineral density lead to substantial morbidity, mortality, and cost to individuals and health systems.
GBD 2021 Low Bone Mineral Density Collaborators
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Road effects on habitat richness of the Greek Natura 2000 network

open access: yesNature Conservation, 2012
The road network has both positive and negative ecological effects, and understanding these helps identify environmentally preferable solutions for transportation policy and planning. We investigated the relationship between road density and habitat type
Nefta Votsi   +6 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

ANALISIS.KERAPATAN JALAN HUTAN BERDASARKAN HASILPENAFSIRAN FOTO UDARA DAN SURVEl LAPANGAN: STUDI KASUS PT.INHUTANI II

open access: yesJurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017
Forest road network has a very important role in tranaporling logs fram the frest to processing site or logyard. The investigation of forest road density by using theaerial photo of l : 20.000 and 1: 60.000 scales had been conducted.The scope of the ...
Ishak Sumantri
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Optimum road spacing of ground based skidding operations in Nowshahr, Iran

open access: yesCaspian Journal of Environmental Sciences, 2008
The optimum road spacing has been studied by many researches. It is an important step of forest road network planning. The goals of this study are determining the optimum road spacing in Kheiroudkenar forest of Nowshahr in Northern Iran and study of ...
Sobhani,H.
doaj  

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