Results 41 to 50 of about 263,030 (253)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Nonlinear impact analysis of built environment on urban road traffic safety risk
Systems Science & Control Engineering, 2023 With the rapid development of economy, the increasing number of motor vehicles and the total road mileage, which leads to the increasingly prominent traffic safety problems.
Zhang Yaofang, Chen Jian, Qiu Zhixuan
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Forestist, 2005 Environment consciousness of puclic opinion is increase recent years. In the management of the forest ecosystem for various purposes, care must be taken not to spoil the forest structure.
Mesut HASDEMİR, Murat DEMİR
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Canadian Planning and Policy, 2020 Roads are an important aspect of the efficiency gains that stem from population density: the more people live on a given road network, the less each person must pay for paving, maintenance, and snow clearing.
Tristan Cleveland +2 more
doaj +1 more source
The impacts of road traffic on urban air quality in Jinan based GWR and remote sensing
Scientific Reports, 2021 Traffic congestion and smog are hot topics in recent years. This study analyzes the impacts of road traffic characteristic parameters on urban air quality quantitatively based on aerosol optical thickness (AOD) and geographical weighted regression (GWR ...
Qi Wang +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Spatial and Temporal Distribution Analysis of Traffic Accidents Using GIS-Based Data in Harbin
Journal of Advanced Transportation, 2021 Road traffic safety is a social issue of widespread concern. It is important for traffic managers to understand the distribution patterns of road traffic accidents.
Meina Wang +4 more
doaj +1 more source