Results 41 to 50 of about 3,805,880 (279)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Investigating the Nonlinear Relationship Between Car Dependency and the Built Environment
Urban Planning, 2023 Car-dominated daily travel has caused many severe and urgent urban problems across the world, and such travel patterns have been found to be related to the built environment. However, few existing studies have uncovered the nonlinear relationship between
Jun Cao +5 more
doaj +1 more source
On-road driving studies to understand why drivers behave as they do at regional rail level crossings [PDF]
, 2013 Improving safety at rail level crossings is an important part of both road and rail safety strategies. While low in number, crashes between vehicles and trains at level crossings are catastrophic events typically involving multiple fatalities and serious
Salmon, P.B. +12 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Roads and Roadless Areas in Cyprus: Implications For The Natura 2000 Network
Journal of Landscape Ecology, 2014 The road network in Cyprus has seen an 88% increase in the last 20 years. This expansion has not been followed by any kind of assessment on the effects of the network on nature conservation.
Zomeni Maria, Vogiatzakis Ioannis. N.
doaj +1 more source
Data fusion algorithms for density reconstruction in road transportation networks [PDF]
2015 54th IEEE Conference on Decision and Control (CDC), 2015 This paper addresses the problem of density reconstruction in traffic networks with heterogeneous information sources. The network is partitioned in cells in which vehicles flow from their origin to their destination. The state of the network is represented by the densities of vehicles in each cell.Density estimation is of crucial importance in future ...
Lovisari, Enrico +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Nonlinear impact analysis of built environment on urban road traffic safety risk
Systems Science & Control Engineering, 2023 With the rapid development of economy, the increasing number of motor vehicles and the total road mileage, which leads to the increasingly prominent traffic safety problems.
Zhang Yaofang, Chen Jian, Qiu Zhixuan
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source