Results 131 to 140 of about 1,161,829 (246)

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Structural and Stability Analysis of de Novo Designed Proteins Incorporating a Plant Self‐Incompatibility Motif

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi, Koya Sakuma, Yoshitaka Moriwaki, Naoki Aoyama, Toma Kashima, Tohru Terada, Akimasa Miyanaga, Shinya Fushinobu   +7 more
wiley   +1 more source

Restoring Lateral Connectivity to Anthropogenic Riverscapes: Six Lessons From Stage Zero

River Research and Applications, EarlyView.
ABSTRACT Centuries of river modification, particularly straightening and incision, have severely reduced lateral connectivity between rivers and their floodplains. As a result, Stage 0 riverscapes, characterised by high lateral connectivity (e.g., anastomosing or wetland riverscapes), are now rare in anthropogenic landscapes.
Richard J. Mason, Matthew F. Johnson, Ben Eardley, Matthew J. Hemsworth, Arnaud Foret, Luca Mao, Matt Parr, Alan Puttock, Richard E. Brazier   +8 more
wiley   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

Multi-hazard exposure in public schools of a medium-sized city: outdoor road dust contamination, and indoor Rn risk. [PDF]

Environ Geochem Health
Almeida L, Rocha F, Pereira A, Sequeira C, Candeias C.   +4 more
europepmc   +1 more source

Reactivity of Oxidized Porous Silicon with Calcium Ion in Aqueous Media: Stability, pH Behavior, and Host‐Guest Strategies

Small, EarlyView.
Oxidized porous silicon, composed of an elemental silicon porous skeleton coated with a silica shell, reacts with aqueous Ca2+ to generate a mixed silica–calcium silicate matrix that is remarkably efficient at trapping small molecules. With an emphasis on the engineering of controlled‐release drug delivery systems, this study identifies the factors ...
Ruhan Fan, Qinglin Yang, Michael J. Sailor   +2 more
wiley   +1 more source

Fugitive dust emissions from off-road vehicle maneuvers on military training lands [PDF]

Master of ScienceDepartment of Biological and Agricultural EngineeringRonaldo G. MaghirangMilitary installations in the United States may be large sources of fugitive dust emissions.
Meeks, Jeremy C.
core  

Inhalation Bioaccessibility, Pollution Assessment, and Speciation of Heavy Metals in PM_2.5RD Road Dust from Urban and Semi-Urban Areas of Pakistan. [PDF]

Toxics
Moryani HT, Zhu SM, Wang LP, Xu B, Yu C, Dong GH.   +5 more
europepmc   +1 more source

Hierarchically Rough rGO/HAp Nanocoatings on SLM Ti–6Al–4 V Implants for Enhanced Biointegration

Small, EarlyView.
This study investigates HAp/rGO bioactive coatings on Ti‐6Al‐4V fixation implants fabricated by selective laser melting with systematically varied volumetric energy density to tailor the as‐built surface state. Composite coatings were deposited by electrophoretic deposition and characterized using micro‐CT, profilometry, FESEM/EDS, and detailed XPS to ...
Muhammad Usama Zaheer, Vahid Jahed, Rajveer Singh Rajaura, Fatemeh Rastegar Adib, Muhammad Hassan Razzaq, Gökhan Demirel, Mobarak Abu Mraheil, Thaqif El Khassawna, Mehmet Fatih Aycan, Yogendra Kumar Mishra   +9 more
wiley   +1 more source