Results 61 to 70 of about 568,064 (340)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Extraction of Roads Using the Archimedes Tuning Process with the Quantum Dilated Convolutional Neural Network

Sensors, 2023
Road network extraction is a significant challenge in remote sensing (RS). Automated techniques for interpreting RS imagery offer a cost-effective solution for obtaining road network data quickly, surpassing traditional visual interpretation methods ...
Mohd Jawed Khan, Pankaj Pratap Singh, Biswajeet Pradhan, Abdullah Alamri, Chang-Wook Lee   +4 more
doaj   +1 more source

An experimental validation of the fatigue damaging events extracted using the wavelet bump extraction (WBE) algorithm [PDF]

, 2004
This paper describes an experimental validation of the fatigue damaging events that were identified and extracted using a wavelet-based fatigue data editing technique.
Abdullah, S, Choi, JC, Giacomin, J, Yates, JR   +3 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Brazil’s Deferred Highway: Mobility, Development, and Anticipating the State in Amazonia [PDF]

, 2012
Four decades ago, Brazilian officials plotted designs for colonization and resource extraction in Amazonia; subsequently the region has become a test-lab for successive development regimes. Along the Santarém-Cuiabá Highway (Br-163) in the state of Pará,
Campbell, Jeremy M.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

WHU-RuR+: A benchmark dataset for global high-resolution rural road extraction

International Journal of Applied Earth Observations and Geoinformation
Efficient and accurate extraction of road networks from high-resolution satellite images is essential for urban planning, construction, and traffic management.
Ningjing Wang, Xinyu Wang, Yang Pan, Wanqiang Yao, Yanfei Zhong   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A new tool to calculate roadless space in forest landscapes, applied in the Congo basin [PDF]

, 2015
New global strategies for road building require innovative tools to analyze linear patterns and their spatial distribution and to evaluate their environmental impacts. Roads not only present physical barriers to wildlife but also provide access for human
Gourlet-Fleury, Sylvie, Healey, John R., Kleinschroth, Fritz, Mortier, Frédéric, Stoica, Radu S.   +4 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source