Results 51 to 60 of about 179,225 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

WHU-RuR+: A benchmark dataset for global high-resolution rural road extraction

International Journal of Applied Earth Observations and Geoinformation
Efficient and accurate extraction of road networks from high-resolution satellite images is essential for urban planning, construction, and traffic management.
Ningjing Wang, Xinyu Wang, Yang Pan, Wanqiang Yao, Yanfei Zhong   +4 more
doaj   +1 more source

Extraction of Roads Using the Archimedes Tuning Process with the Quantum Dilated Convolutional Neural Network

Sensors, 2023
Road network extraction is a significant challenge in remote sensing (RS). Automated techniques for interpreting RS imagery offer a cost-effective solution for obtaining road network data quickly, surpassing traditional visual interpretation methods ...
Mohd Jawed Khan, Pankaj Pratap Singh, Biswajeet Pradhan, Abdullah Alamri, Chang-Wook Lee   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

SWCARE: Switchable learning and connectivity-aware refinement method for multi-city and diverse-scenario road mapping using remote sensing images

International Journal of Applied Earth Observations and Geoinformation
Accurate and efficient mapping of road networks is crucial for evaluating urban development, transportation accessibility, and environmental impact.
Lixian Zhang, Shuai Yuan, Runmin Dong, Juepeng Zheng, Bin Gan, Dengmao Fang, Yang Liu, Haohuan Fu   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

WeavingUnet: Enhancing dense road extraction by integrating horizontal and vertical features

International Journal of Applied Earth Observations and Geoinformation
Road extraction plays a crucial role in automatically identifying road networks from remote sensing images, which is essential for various applications. However, existing road extraction methods perform poorly when dealing with dense roads.
Xianzhi Ma, Jianhui Li, Mingyang Lv
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Feature Fusion Based Road Extraction for HJ-1-C SAR Image

Leida xuebao, 2014
Road network extraction in SAR images is one of the key tasks of military and civilian technologies. To solve the issues of road extraction of HJ-1-C SAR images, a road extraction algorithm is proposed based on the integration of ratio and directional ...
Lu Ping-ping, Du Kang-ning, Yu Wei-dong, Wang Yu, Deng Yun-kai   +4 more
doaj   +1 more source