Results 61 to 70 of about 2,255,908 (239)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
International Journal of Applied Earth Observations and GeoinformationAccurate and efficient mapping of road networks is crucial for evaluating urban development, transportation accessibility, and environmental impact.
Lixian Zhang +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
WHU-RuR+: A benchmark dataset for global high-resolution rural road extraction
International Journal of Applied Earth Observations and GeoinformationEfficient and accurate extraction of road networks from high-resolution satellite images is essential for urban planning, construction, and traffic management.
Ningjing Wang +4 more
doaj +1 more source
Automatic Road Centerline Extraction from Imagery Using Road GPS Data
Remote Sensing, 2014 Road centerline extraction from imagery constitutes a key element in numerous geospatial applications, which has been addressed through a variety of approaches.
Chuqing Cao, Ying Sun
doaj +1 more source
Sensors, 2023 Road network extraction is a significant challenge in remote sensing (RS). Automated techniques for interpreting RS imagery offer a cost-effective solution for obtaining road network data quickly, surpassing traditional visual interpretation methods ...
Mohd Jawed Khan +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
WeavingUnet: Enhancing dense road extraction by integrating horizontal and vertical features
International Journal of Applied Earth Observations and GeoinformationRoad extraction plays a crucial role in automatically identifying road networks from remote sensing images, which is essential for various applications. However, existing road extraction methods perform poorly when dealing with dense roads.
Xianzhi Ma, Jianhui Li, Mingyang Lv
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source