Results 41 to 50 of about 10,524 (261)

Regularities of defect development in the asphalt concrete road pavements

Journal of Civil Engineering and Management, 2002
A new classification of asphalt concerete pavement defects is presented in the article and the causes of their development are systematised. The dynamics of asphalt concrete pavement defect development in the road and the dependence of pavement ...
Henrikas Sivilevičius, Kazys Petkevičius   +1 more
doaj   +1 more source

Determination of permanent deformation of flexible pavements using finite element model

Građevinar, 2022
The unbound granular material used in flexible road pavements exhibits an elastoplastic behaviour under repetitive traffic loads. Permanent deformation occurring on pavement surface under traffic load is one of the main road pavement problems affecting ...
Huseyin Karadag, Seyhan Firat, Nihat Sinan Isik, Gulgun Yilmaz   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Complex coefficient for assessing the condition of the road surface [PDF]

Дороги і мости
Introduction. This article deals with the issue of reviewing existing methods and approaches to assessing the condition of the road pavement and proposes a methodology for assessing the condition of the road pavement using a complex indicator.
Igor Gameliak, Vitaliy Raykovskiy
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Self-healing Asphalt for Road Pavements

, 2020
This paper presents a unique self-healing system for asphalt pavement which employs compartmented calcium-alginate fibres encapsulating an asphalt binder healing agent (rejuvenator). This system presents a novel method of incorporating rejuvenators into asphalt pavement mixtures.
Tabakovic, A. (author), Schlangen, E. (author)   +1 more
openaire   +5 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Analysis of flexible pavement performance prediction models based on structural behaviour

Roads and Bridges, 2019
Sustainable and durable road pavement requires appropriate maintenance and repair strategies. National road authorities collect data describing pavement condition every several years and use specific life-cycle analysis methods to draw up priority plans ...
Paulius Paplauskas, Audrius Vaitkus, Rita Kleizienë   +2 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source