Results 31 to 40 of about 1,546,705 (251)

Updating predictive accident models of modern rural single carriageway A-roads [PDF]

open access: yes, 2012
Reliable predictive accident models (PAMs) are essential to design and maintain safe road networks and yet the models most commonly used in the UK were derived using data collected 20 to 30 years ago.
Alan G. Wood   +4 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter   +17 more
wiley   +1 more source

Performance and Reinforcement Mechanism of Modified Asphalt Binders with Nano-Particles, Whiskers, and Fibers

open access: yesApplied Sciences, 2019
The asphalt binders could be modified to improve road perfo rmances by using various methods, and the reinforcement mechanisms are obviously different and quietly affect the road performances.
Xiangyang Xing   +6 more
doaj   +1 more source

Sustainable infrastructure procurement in Australia: Standard vs. project practices [PDF]

open access: yes, 2013
The Australian Government and most Australian road authorities have set ambitious greenhouse gas emission (GHGe) reduction targets for the near future, many of which have translated into action plans. However, previous research has shown that the various
Hampson, Keith   +3 more
core   +2 more sources

Effect of road layout and road environment on driving performance, drivers' physiology and road appreciation

open access: yesErgonomics, 1995
Infrastructural changes were implemented on rural 80 km/h roads in The Netherlands in an effort to reduce speeding. The road infrastructure changes were designed to produce discomfort for the speeding driver by providing noxious auditory and haptic feedback.
De Waard, D.   +4 more
openaire   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Does Familiarity breed inattention? Why drivers crash on the roads they know best [PDF]

open access: yes, 2012
This paper describes our research into the nature of everyday driving, with a particular emphasis on the processes that govern driver behaviour in familiar, well - practiced situations.
Charlton, Samuel G., Starkey, Nicola J.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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