Results 41 to 50 of about 12,163 (214)
Evaluation of road performance and micro-mechanism analysis of bentonite plastic concrete subgrade
Materials Research ExpressThis study evaluated the performance of bentonite plasticized concrete with good deformation coordination as a road base material, to address the poor deformation coordination of rigid base layers in roads.
Zhang Guoming +6 more
doaj +1 more source
Behavioral SciencesThe purpose of this study was to investigate the influence of an identity leadership-framed reflective practice intervention on perceptions of leadership, social identity, and psychological safety in cricket.
Adam Hoult +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
BiomoleculesObjective: Impaired fatty acid oxidation (FAO) is considered an important metabolic mechanism underlying skeletal muscle aging and sarcopenia; however, the key regulatory molecules involved in this process remain incompletely defined. This study aimed to
Haoyang Gao +7 more
doaj +1 more source
The recycling of construction waste asphalt mixes – study case [PDF]
Archives of Civil EngineeringConstruction waste (CW) has become one of the main factors exacerbating regional environmental damage, and how to recycle and utilize CW as a resource is also a key focus of future urban construction in China.
Mengya Jiang, Xiaoqing Cai
doaj +1 more source
The Impact of Grain Crushing on Road Performance
Geotechnical and Geological Engineering, 2009 This paper presents the results of a study of grain crushing in road construction and its effect on road behaviour. Sieve analyses of field samples confirmed that grain crushing occurs during compaction of the base layer despite the good quality of aggregates used.
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
BuildingsReflection cracks significantly compromise the service life of half-rigid asphalt pavements in cold regions. This study introduces SAKIII warm-mixed rubber–asphalt mixture (SAKIII WMRA Mix) as a stress absorption layer to address this issue.
Rui Pan, Jifeng Chang, Yu Chen
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source