Results 61 to 70 of about 1,546,705 (251)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
BuildingsReflection cracks significantly compromise the service life of half-rigid asphalt pavements in cold regions. This study introduces SAKIII warm-mixed rubber–asphalt mixture (SAKIII WMRA Mix) as a stress absorption layer to address this issue.
Rui Pan, Jifeng Chang, Yu Chen
doaj +1 more source
Prioritization of Road Network Construction in Bacan Island of North Maluku Province [PDF]
, 2013 Bacan Island, located in South Halmahera, North Maluku Province, is a potential region with a variety of important sectors, such as plantations, fisheries, mining, tourism, industry and trade.
Bowoputro, H. (Hendi) +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Road Performance of Mica Powder Modified Asphalt Mixture
Kuangchan zonghe liyongThis is an article in the field of ceramics and composites. In order to investigate the basic road performance of mica powder modified asphalt mixture, modified asphalt with 0%, 3%, 5%, 7%, 9%, and 11% content was prepared.
Chao FENG +4 more
doaj +1 more source
Mechanical Properties of Sandstone Cement-Stabilized Macadam
Applied Sciences, 2019 Application of sandstone in cement-stabilized macadam (CSM) is an effective way to utilize sandstone. To determine the feasibility of using sandstone as a CSM aggregate, a series of experimental investigations, such as unconfined compressive strength ...
Qiang Du +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
EVALUASI KINERJA RUAS JALAN RAYA MOJOSARI DESA MOJOSARI KECAMATAN KEPANJEN KABUPATEN MALANG [PDF]
One of the many routes that connects Malang Regency with the City Malang is the Mojosari Highway part of Malang Regency. This road is busy with traffic activity and busy with activities along the sides of the road.
Merany, Razar
core
The technological model of operating area by the combined transport [PDF]
, 2009 The contribution deals with design technology service model using the combined transport. It assesses the performance indicators in relation to price and quality of services provided and on this basis decides on the type of the transport.
Cempírek, Václav +2 more
core +1 more source