Results 71 to 80 of about 1,546,705 (251)

The price of anarchy in transportation networks by estimating user cost functions from actual traffic data [PDF]

, 2016
We have considered a large-scale road network in Eastern Massachusetts. Using real traffic data in the form of spatial average speeds and the flow capacity for each road segment of the network, we converted the speed data to flow data and estimated the ...
Cassandras, Christos G., Paschalidis, Ioannis Ch., Pourazarm, Sepideh, Zhang, Jing   +3 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Preparation and Properties of Waterborne Polyurethane and SBS Composite-Modified Emulsified Asphalt

Applied Sciences
To address the issue of insufficient durability of traditional modified emulsified asphalt in the application of cold mix and cold paving anti-skid wear layers, this study utilizes cationic waterborne polyurethane (PU+) for composite modification to ...
Ruiqi Chen, Wen Xu, Yixing Chen
doaj   +1 more source

Road Extraction by Deep Residual U-Net

, 2017
Road extraction from aerial images has been a hot research topic in the field of remote sensing image analysis. In this letter, a semantic segmentation neural network which combines the strengths of residual learning and U-Net is proposed for road area ...
Liu, Qingjie, Wang, Yunhong, Zhang, Zhengxin   +2 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Research on the Properties of Nano-Al₂O₃- and Nano-SiO₂-Modified Bio-Asphalt and Mixtures

Buildings
Bio-oil as a substitute or modifier for petroleum asphalt has significant environmental, economic, and sustainable development implications. However, the insufficient high-temperature and anti-aging characteristics of bio-asphalt lead to the limited ...
Wei Qiao, Feilong Yuan, Xiaojian Xu, Qingzhou Wang   +3 more
doaj   +1 more source

A Geo-Statistical Analysis of Road Mortality in the Enlarged EU [PDF]

This paper aims at showing and understanding the spatial regional disparities hidden behind average national statistics on road fatalities in Europe; special attention is given on the EU last enlargement.
Isabelle Thomas, Sylvain Lassarre, Vojtech Eksler   +2 more
core  

A two-dimensional data-driven model for traffic flow on highways

, 2017
Based on experimental traffic data obtained from German and US highways, we propose a novel two-dimensional first-order macroscopic traffic flow model. The goal is to reproduce a detailed description of traffic dynamics for the real road geometry. In our
Fazekas, Adrian, Herty, Michael, Visconti, Giuseppe   +2 more
core   +1 more source