Results 71 to 80 of about 12,826,919 (257)

On street parking and its impact on road performance

, 2018
Commercial areas have a high economic and parking activity. High parking activity that is not comparable to the availability of parking facilities and it can interfere with the performance of the road.
S. Sulistyono, Harnen Sulistio, L. Djakfar, A. Wicaksono, Ririn Endah Badriani   +4 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of Fiber Diameter On-Road Performance of Cement-Stabilized Macadam

, 2017
Cement-stabilized macadam is the most widely used road base material in road engineering. The current study investigated the impact of fiber diameter on its performance.
L. Zhijun, Dongquan Wang, Wei Xiaobi, L. Wang   +3 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Preparation and Properties of Waterborne Polyurethane and SBS Composite-Modified Emulsified Asphalt

Applied Sciences
To address the issue of insufficient durability of traditional modified emulsified asphalt in the application of cold mix and cold paving anti-skid wear layers, this study utilizes cationic waterborne polyurethane (PU+) for composite modification to ...
Ruiqi Chen, Wen Xu, Yixing Chen
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Research on the Properties of Nano-Al₂O₃- and Nano-SiO₂-Modified Bio-Asphalt and Mixtures

Buildings
Bio-oil as a substitute or modifier for petroleum asphalt has significant environmental, economic, and sustainable development implications. However, the insufficient high-temperature and anti-aging characteristics of bio-asphalt lead to the limited ...
Wei Qiao, Feilong Yuan, Xiaojian Xu, Qingzhou Wang   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Study of Low-Content Epoxy Asphalt Mixture Applied to the Road

Buildings
To realize the application of epoxy asphalt concrete on roads and solve the problem of the high cost of epoxy asphalt concrete and the causes of bulging in the construction process, a low-content epoxy asphalt mixture was experimentally studied ...
Xiaodong Li, Chuanxi Luo, Shaohuai Wang, Xiang Long, Yan Wang, Jian Li, Mu He   +6 more
doaj   +1 more source