Results 71 to 80 of about 9,513,060 (240)

Research on the Properties of Nano-Al₂O₃- and Nano-SiO₂-Modified Bio-Asphalt and Mixtures

Buildings
Bio-oil as a substitute or modifier for petroleum asphalt has significant environmental, economic, and sustainable development implications. However, the insufficient high-temperature and anti-aging characteristics of bio-asphalt lead to the limited ...
Wei Qiao, Feilong Yuan, Xiaojian Xu, Qingzhou Wang   +3 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Study of Low-Content Epoxy Asphalt Mixture Applied to the Road

Buildings
To realize the application of epoxy asphalt concrete on roads and solve the problem of the high cost of epoxy asphalt concrete and the causes of bulging in the construction process, a low-content epoxy asphalt mixture was experimentally studied ...
Xiaodong Li, Chuanxi Luo, Shaohuai Wang, Xiang Long, Yan Wang, Jian Li, Mu He   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Influence of Ultra-Fine Iron Tailings Sand on Performance of Cement-Stabilized Macadam Base

Zhongwai Gonglu
To study the application potential of ultra-fine iron tailings sand (UITS) as a road base material, this paper conducted unconfined compressive strength (UCS) tests and freezing and thawing tests to systematically analyze the effects of UITS content and ...
MENG Delong, LI Hongzhen, CHEN Fushen, WANG Keran, JIANG Yuntao, CHEN Lei, FENG Zhuangzhuang   +6 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Study on the influence of matrix asphalt mixture air voids on the performance of semi-flexible pavement materials

Frontiers in Materials
In practical applications, semi-flexible pavement materials need to achieve a balance between mechanical properties, high-temperature stability, cracking resistance, and water stability.
Jie Chen, Jie Chen, Jie Chen, Zhiyu Yang, Hui Huang, Hui Huang, Jiechao Lei, Jiechao Lei, Weian Xuan, Weian Xuan   +9 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Road Accident Data, 1989

, 2006
copyright UK Data Service and data collection copyright owner.Road accident statistics are collected from information about personal injury road accidents and their consequent casualties, to a common national standard.
Department of Transport, Road Accident Statistics Branch
core   +1 more source