Results 91 to 100 of about 237,968 (367)

Traffic congestion a negative component of sustainable development of modern road transport system [PDF]

Journal of Research and Innovation for Sustainable Society
Traffic congestion in major cities continues to deteriorate as a consequence of the continued development of the economy, resulting in lost time in traffic, increased risk of accidents, pollution and many other negative externalities for urban and non ...
Gheorghe Neamțu, Marinela Ință, Ioan Țincu   +2 more
doaj  

Evaluation of City Planning Road Development Measures by Microscopic Traffic Simulation [PDF]

This study was made on the development plan of Kawahara Avenue, a road project authorized in city planning of Miyazaki City in Japan. The Kawahara Avenue development is planned along the Oyodo River. The land use of the area along the route comprises the
Tetsunobu Yoshitake, Masaya Kawano, Satoshi Toi, Hiroshi Tatsumi, Yoshitaka Kajita   +4 more
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Time, speeds, flows and densities in static models of road traffic congestion and congestion pricing [PDF]

This paper deals with some of the features of static models of road traffic congestion that have caused much debate in the literature. It first focuses on the difficulties arising with the backward-bending cost curve defined over traffic flows in the ...
Erik Teodoor Verhoef
core  

Modelling road traffic incident management problems for automated planning

, 2012
This paper is concerned with the application of automated planning in assisting the decision making and logistics in the area of Road Traffic Incidents.
Jimoh, F., McCluskey, T.L., Shah, M., Gregory, P.   +3 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Congestion Prediction With Big Data for Real-Time Highway Traffic

IEEE Access, 2018
By collecting and analyzing a vast quantity and different categories of information, traffic flow and road congestion can be predicted and avoided in intelligent transportation system.
Fan-Hsun Tseng, Jen-Hao Hsueh, Chia-Wei Tseng, Yao-Tsung Yang, Han-Chieh Chao, Li-Der Chou   +5 more
doaj   +1 more source

HIPERTRANS: a road traffic simulation as an operational tool

, 1998
The HIPERTRANS (High Performance Transport Network Modelling and Simulation) project is developing a simulation tool that will provide a new range of facilities for road transport consultants, traffic engineers and urban traffic control centre (UTC ...
Kalantery, N., Daniels, B.K., Ijaha, S., Winter, S.   +3 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source