Results 101 to 110 of about 237,968 (367)

Nonlinear Effects of Multiscale Road Network Features on Traffic Accidents

open access: yesRedai dili
Amidst rapid motorization, urban road traffic safety has become increasingly critical. As a fundamental framework of traffic systems, road networks strongly influence the occurrence of traffic accidents.
Zhou Fangyu, Xie Bo, Xiao Yangmou
doaj   +1 more source

Road traffic injury prevention [PDF]

open access: yesBMJ, 2004
WHO report advocates input from public health and a systems approach “A 63-year-old woman was in critical condition last night after being struck by a car… as she crossed Sherbrooke St E shortly after 4 pm… It appears the pedestrian and motorist both had a green light, said Constable Lapointe.
openaire   +2 more sources

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon   +21 more
wiley   +1 more source

Dynamic load balancing of parallel road traffic simulation [PDF]

open access: yes, 2010
The objective of this research was to investigate, develop and evaluate dynamic load-balancing strategies for parallel execution of microscopic road traffic simulations.
Igbe, D.
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

open access: yesAdvanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li   +8 more
wiley   +1 more source

On-road driving studies to understand why drivers behave as they do at regional rail level crossings

open access: yes, 2013
Improving safety at rail level crossings is an important part of both road and rail safety strategies. While low in number, crashes between vehicles and trains at level crossings are catastrophic events typically involving multiple fatalities and serious
Salmon, P.B.   +12 more
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

open access: yesAdvanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang   +10 more
wiley   +1 more source

Road traffic facilities, traffic accidents, and poverty: Lesson learned from Indonesia

open access: yesTransportation Research Interdisciplinary Perspectives
The development of road traffic facilities is progressing rapidly in both developed and developing countries. However, the number of deaths caused by road traffic accidents is still increasing and the families of the accident victims are trapped in ...
Iwan Hermawan   +9 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

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