Results 241 to 250 of about 2,416,136 (291)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Do Product Market Reforms Work? Assessing Regulatory Changes Impacting Competition

Southern Economic Journal, EarlyView.
ABSTRACT We create a new dataset that characterizes studies of product market reforms implemented from 1932 to 2011. We examine the size and origins of differences in estimated impacts based on an OECD classification scheme for potentially competitive restrictions of regulation. The median impact from switching to a pro‐competitive environment is a 19%
Sean F. Ennis, Selvin Thanacoody
wiley   +1 more source

From Map Follower to Navigator: Archetypes of Environmental Impact Assessment

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Environmental impact assessment (EIA) scholarship is commonly framed as a tension between efficiency and comprehensiveness paradigms. These paradigms describe a persistent tension but cannot explain how EIA operates through it. Drawing on social systems theory, this analysis traces that operation.
Kenneth Kang
wiley   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Causes, treatment and outcome of external ear canal tears and avulsions in cats and dogs: 24 cases (2008‒2024)

Veterinary Record, EarlyView.
Abstract Background This study aimed to evaluate the causes, treatment options and associated complications of ear canal tears and avulsions in dogs and cats. Methods This retrospective clinical study includes 14 cats and 10 dogs diagnosed with external ear canal tears and avulsions using otoscopy and/or computed tomography.
Eva M. Billau, Cetina Thiel
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Road traffic injuries--a neglected pandemic.

Bulletin of the World Health Organization, 2004
openaire   +2 more sources

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source