Results 21 to 30 of about 2,250 (168)

seq-seq-pan: building a computational pan-genome data structure on whole genome alignment

BMC Genomics, 2018
Background The increasing application of next generation sequencing technologies has led to the availability of thousands of reference genomes, often providing multiple genomes for the same or closely related species.
Christine Jandrasits, Piotr W. Dabrowski, Stephan Fuchs, Bernhard Y. Renard   +3 more
doaj   +1 more source

Completeness of tuberculosis case notifications in Germany in 2013–2017: first results of an inventory study

BMC Infectious Diseases, 2020
Background Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013–2017.
Teresa Domaszewska, Basel Karo, Ute Preuss, Christian Kollan, Annicka Reuss, Hans-Peter Blank, Bonita Brodhun, Barbara Hauer, Doris Altmann, Lena Fiebig, Walter Haas, Nita Perumal   +11 more
doaj   +1 more source

SARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in Germany

Frontiers in Public Health, 2021
Introduction: Until today, the role of children in the transmission dynamics of SARS-CoV-2 and the development of the COVID-19 pandemic seems to be dynamic and is not finally resolved.
Anja Schienkiewitz, Susanne Jordan, Anselm Hornbacher, Hanna Perlitz, Marie-Luise Zeisler, Anna Sandoni, Ulrike Kubisch, Barbara Wess, Tim Kuttig, Angelika Schaffrath-Rosario, Stefan Damerow, Petra Rattay, Gianni Varnaccia, Anne-Kathrin M. Loer, Jan Wormsbächer, Carolin Cohrdes, Matthias Wetzstein, Stefan Albrecht, Isabell Hey, Janine Michel, Livia Schrick, Antje Gößwald, Jennifer Allen, Martin Schlaud, Markus A. Busch, Hans Butschalowsky, Jörg Wernitz, Eveline Otte im Kampe, Udo Buchholz, Walter Haas, Lars Schaade, Lothar H. Wieler, Lothar H. Wieler, Thomas Ziese, Thomas Lampert, Julika Loss   +35 more
doaj   +1 more source

New data for action. Data collection for KiGGS Wave 2 has been completed [PDF]

Journal of Health Monitoring, 2017
The fieldwork of the second follow-up to the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) was completed in August 2017. KiGGS is part of the Robert Koch Institute’s Federal Health Monitoring.
Elvira Mauz, Antje Gößwald, Panagiotis Kamtsiuris, Robert Hoffmann, Michael Lange, Ursula von Schenck, Jennifer Allen, Hans Butschalowsky, Laura Frank, Heike Hölling, Robin Houben, Laura Krause, Ronny Kuhnert, Cornelia Lange, Stephan Müters, Hannelore Neuhauser, Christina Poethko-Müller, Almut Richter, Angelika Schaffrath Rosario, Jörg Schaarschmidt, Robert Schlack, Martin Schlaud, Patrick Schmich, Gina Schöne, Matthias Wetzstein, Thomas Ziese, Bärbel-Maria Kurth   +26 more
doaj   +1 more source

Seroepidemiological study on the spread of SARS-CoV-2 in populations in especially affected areas in Germany – Study protocol of the CORONA-MONITORING lokal study [PDF]

Journal of Health Monitoring, 2020
At a regional and local level, the COVID-19 pandemic has not spread out uniformly and some German municipalities have been particularly affected. The seroepidemiological data from these areas helps estimate the proportion of the population that has been ...
Claudia Santos-Hövener, Markus A. Busch, Carmen Koschollek, Martin Schlaud, Jens Hoebel, Robert Hoffmann, Hendrik Wilking, Sebastian Haller, Jennifer Allen, Jörg Wernitz, Hans Butschalowsky, Tim Kuttig, Silke Stahlberg, Julia Strandmark, Angelika Schaffrath Rosario, Antje Gößwald, Andreas Nitsche, Osamah Hamouda, Christian Drosten, Victor Corman, Lothar H. Wieler, Lars Schaade, Thomas Lampert   +22 more
doaj   +1 more source

The PadR-like transcriptional regulator LftR ensures efficient invasion of Listeria monocytogenes into human host cells

Frontiers in Microbiology, 2015
Invasion of the bacterial pathogen Listeria monocytogenes into human host cells requires specialized surface molecules for attachment and induction of phagocytosis.
Karan Gautam Kaval, Birgitt eHahn, Nayana eTusamda, Dirk eAlbrecht, Sven eHalbedel   +4 more
doaj   +1 more source

Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control

BMC Infectious Diseases, 2017
Background Herpes simplex infections (HSV1/2) are characterized by recurrent symptoms, a risk of neonatal herpes, and the facilitation of HIV transmission. In Germany, HSV1/2 infections are not notifiable and data are scarce.
Gerit Korr, Michael Thamm, Irina Czogiel, Christina Poethko-Mueller, Viviane Bremer, Klaus Jansen   +5 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

HERV-K(HML-2), the best preserved family of HERVs: endogenisation, expression and implications in health and disease

Frontiers in Oncology, 2013
Retroviruses that have the ability to infect germ line cells can become an integral and inherited part of the host genome. About 8% of the human chromosomal DNA consists of sequences derived from infections by retroviruses that presumably circulated 2-40
Oliver eHohn, Kirsten eHanke, Norbert eBannert   +2 more
doaj   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source