Results 81 to 90 of about 313,849 (316)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Construction robotics

Autonomous Robots, 2006
[abstFig src='/00280002/01.jpg' width=""300"" text='A humanoid robot riding an excavator' ]The following article reviews past and current tendencies and derives and describes opportunities for construction robotics and automation. There substantial evidence in the construction industry, that conventional construction methodology has reached its limits.
openaire   +1 more source

Co-Robots as Care Robots

CoRR, 2020
Accepted paper of the AAAI 2020 Spring Symposium "Applied AI in Healthcare: Safety, Community, and the Environment" (Stanford University).
openaire   +2 more sources

Planning and Real Time Control of a Minimally Invasive Robotic Surgery System

, 2009
This paper introduces the planning and control software of a teleoperating robotic system for minimally invasive surgery. It addresses the problem of how to organize a complex system with 41 degrees of freedom including robot setup planning, force ...
Hirzinger, Gerd, Tobergte, Andreas, Konietschke, Rainer   +2 more
core  

A hand-guided robotic drill for cochleostomy on human cadavers [PDF]

, 2018
Background: An arm supported robotic drill has been recently demonstrated for preparing cochleostomies in a pilot research clinical trial. In this paper, a hand-guided robotic drill is presented and tested on human cadaver trials. Methods: The innovative
Richard Irving, Du, X, Yu Zhang, Zhang, Y, Philip Begg, Brett, PN, Alistair Mitchell-Innes, Mitchell-Innes, A, Peter N Brett, Begg, P, Irving, R, Christopher Coulson, Coulson, C, Xinli Du   +13 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Radical nephrectomy performed by open, laparoscopy with or without hand-assistance or robotic methods by the same surgeon produces comparable perioperative results

International Brazilian Journal of Urology, 2006
PURPOSE: Radical nephrectomy can be performed using open or laparoscopic (with or without hand assistance) methods, and most recently using the da Vinci Surgical Robotic System.
Tanya Nazemi, Anton Galich, Samuel Sterrett, Douglas Klingler, Lynette Smith, K.C. Balaji   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Beyond observation: Deep learning for animal behavior and ecological conservation

Ecological Informatics
Recent advancements in deep learning have profoundly impacted the field of animal behavioral research, offering researchers powerful tools for understanding the complexities of animal movements and cognition.
Lyes Saad Saoud, Atif Sultan, Mahmoud Elmezain, Mohamed Heshmat, Lakmal Seneviratne, Irfan Hussain   +5 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source