Results 291 to 300 of about 3,396,076 (388)

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo   +20 more
wiley   +1 more source

Reconstructing Three‐Dimensional Optical Anisotropy with Tomographic Müller‐Polarimetric Microscopy

open access: yesAdvanced Science, EarlyView.
Tomographic Müller polarimetric microscopy is a novel imaging technique that resolves 3D birefringent properties of bulky samples, unveiling hierarchical nanostructures at microscopic resolution. Based on incoherent visible‐light polarimetry, it achieves experimental simplicity by eliminating phase measurements.
Yang Chen   +4 more
wiley   +1 more source

A Full‐Range Proximity‐Tactile Sensor Based on Multimodal Perception Fusion for Minimally Invasive Surgical Robots

open access: yesAdvanced Science, EarlyView.
A full‐range proximity‐tactile sensing module is developed for safe operation of surgical robots, which performs multimodal fusion perception through ultrasonic sensor for long‐range proximity detection, capacitive sensor for close‐range proximity sensing, and triboelectric sensor for tactile sensing.
Dongsheng Li   +8 more
wiley   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

open access: yesAdvanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang   +9 more
wiley   +1 more source

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang   +23 more
wiley   +1 more source

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