Results 41 to 50 of about 1,772,869 (315)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Oncological outcomes of extended versus standard pelvic lymph node dissection in radical cystectomy: An updated systematic review and meta‐analysis

BJUI Compass
Objective This study aims to evaluate whether extended lymph node dissection (ePLND) improves overall survival (OS) and oncological outcomes compared with standard dissection (sPLND) in patients undergoing radical cystectomy for urothelial bladder cancer.
Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barretto, Rodrigo Barbosa Freire Silvão, Felipe Pereira Garrido Pazos, Pedro Rodrigues Queiroz, Matheus Oliveira Figueiredo, Ricardo Andrade Freitas Souza, João Pedro Gomes daConceição Oliva, Luma Gabriella Firme Sampaio Góes, Rafael Cintra Rosa Corrêa Oliveira, Lorena Barboza deSousa, Felipe Pinho, Albuquerque Silva, Leonardo Marques Calazans, Wendel Souza Kruschewsky, Alexandre Azevedo Ziomkowski, Eduardo Deda Mendonça Filho, Gabriel Silva Rocha, Marcos Tobias‐Machado, Raphael Brandão Moreira   +19 more
doaj   +1 more source

Robot-Assisted Excision of a Pararectal Gastrointestinal Stromal Tumor in a Patient with Previous Ileal Neobladder

Case Reports in Urology, 2014
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract with surgical resection remaining the cornerstone of therapy.
A. Ploumidis, A. Mottrie, A. F. Spinoit, M. Gan, V. Ficarra, R. Andrianne   +5 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Does Prior Laparoscopic and Open Surgery Experience Have Any Impact on Learning Curve in Transition to Robotic Surgery?

, 2016
It has been 15 years since the Food And Drug Administration approved the Da Vinci® robotic surgery system. Robotic applications are being used extensively in urology, particularly in radical prostatectomy.
Cemil Uygur, Cüneyt Adayener, Tolga Okutucu, Tolga Muharrem Okutucu   +3 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Robotic Surgery for Rectal Cancer and Cost-Effectiveness [PDF]

, 2019
Robotic surgery is considered as one of the advanced treatment modality of minimally invasive surgery for rectal cancer. Robotic rectal surgery has been performed for three decades and its application is gradually expanding along with technology ...
박은정, 백승혁, 전영배
core   +1 more source

Short learning curve in transition from laparoscopic to robotic-assisted rectal cancer surgery: a prospective study from a Finnish Tertiary Referral Centre

, 2023
The narrow pelvis causes special challenges in surgery, and robotic-assisted surgery has been proven beneficial in these circumstances. While robotic surgery has some specific advantages in rectal cancer surgery, there is still limited evidence of the ...
Sannamari Kotaluoto, Marja Hyöty, Ilona M. Helavirta, Mika T. Ukkonen, Johanna M. Laukkarinen, Tomminen, Timo, Kotaluoto, Sannamari, Charlotta S. J. Kolehmainen, Laukkarinen, Johanna M., Timo Tomminen, Helavirta, Ilona M., Ukkonen, Mika T., Hyöty, Marja, Kolehmainen, Charlotta S.J.   +13 more
core   +1 more source

Robotic-assisted abdominal aortic surgery: evidence and techniques [PDF]

, 2022
In various disciplines, robotic-assisted surgery is a well-proven routine procedure, but have never been established in vascular surgery so far. This review summarizes the results to date of robotic-assisted abdominal aortic surgery (RAAS) in the ...
Cremer, Jochen, Berndt, Rouven, Rusch, Melanie, Rusch, René, Hoffmann, Grischa, Jochen Cremer, Rouven Berndt, Grischa Hoffmann, René Rusch, Melanie Rusch   +9 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source