Results 61 to 70 of about 2,815,089 (298)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative Study of Ergonomics in Conventional and Robotic-Assisted Laparoscopic Surgery

Sensors
BACKGROUND: This study aims to implement a set of wearable technologies to record and analyze the surgeon’s physiological and ergonomic parameters during the performance of conventional and robotic-assisted laparoscopic surgery, comparing the ergonomics ...
Manuel J. Pérez-Salazar, Daniel Caballero, Juan A. Sánchez-Margallo, Francisco M. Sánchez-Margallo   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

ACPGBI position statement on robotic‐assisted colorectal surgical training [PDF]

© 2025 The Author(s). Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.The uptake of robotic-assisted colorectal surgery (RACS) across the UK and Ireland has increased ...
Shakir, Taner, Davies, Richard Justin, Eardley, Nicola, Harji, Deena P, Khan, Jim, The Dukes Club, Evans, Charles, Shaikh, Irshad, The Association of Coloproctology of Great Britain and Ireland (ACPGBI) Robotic Clinical Advisory Group, Kinross, James, El‐Sayed, Charlotte, Miskovic, Danilo   +11 more
core   +1 more source

Determining the Reliability of a Robotic Surgical System for Producing Good Clinical Outcomes [PDF]

, 2020
A method to determine the reliability of a robotic surgical system for producing good clinical outcomes is described herein. The method utilizes machine learning (ML) or artificial intelligence (AI) to classify, analyze, or rank how reliable a robotic ...
THINK Surgical, Inc.
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Robotic single-port plus one-port splenic vessel-conserving spleen-preserving distal pancreatectomy: a case report

Journal of Minimally Invasive Surgery
Minimally invasive distal pancreatectomy is a safe and effective surgical approach for the treatment of distal pancreatic tumors. Recently, the da Vinci single-port (SP) system (Intuitive Surgical, Inc.) was introduced to overcome the previously known ...
Sung Hyun Kim, Na Reum Kim, Chang Moo Kang   +2 more
doaj   +1 more source

Advanced real-time multi-display educational system (ARMES): An innovative real-time audiovisual mentoring tool for complex robotic surgery

, 2017
INTRODUCTION: The recent scientific and technologic advances have profoundly affected the training of surgeons worldwide. We describe a novel intraoperative real-time training module, the Advanced Robotic Multi-display Educational System (ARMES ...
손태일, 형우진, 김형일, Kim, Hyoung-Il, Son, Taeil, Woo Jin Hyung, Woo, Yanghee, Taeil Son, Yanghee Woo, Tanaka, Eiji, Eiji Tanaka, Lee, Joong Ho, Ali, Guener, Hyoung-Il Kim, Hyung, Woo Jin, Güner Ali, Joong Ho Lee   +16 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Robotic surgery in eye care: A comprehensive review

Journal of Clinical Ophthalmology and Research
Robotic surgery represents an innovative frontier in ophthalmology, aiming to enhance precision, reduce surgical complications, and expand the potential for minimally invasive procedures.
Jatinder Bali, Nandan Bali
doaj   +1 more source