Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
An integrated SMC-NADRC robust control approach for electric power steering systems considering nonlinear friction and parametric uncertainties. [PDF]
PLoS OneNguyen TA, Nguyen DN.
europepmc +1 more source
High precision robust control design of piezoelectric nanopositioning platform. [PDF]
Sci Rep, 2022 Feng H, Pang A, Zhou H.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
An Integrated Cyber-Physical Digital Twin Architecture with Quantitative Feedback Theory Robust Control for NIS2-Aligned Industrial Robotics. [PDF]
Sensors (Basel)Karlova-Sergieva V +2 more
europepmc +1 more source
Improved Dynamic Event-Triggered Robust Control for Flexible Robotic Arm Systems with Semi-Markov Jump Process. [PDF]
Sensors (Basel), 2023 Zhang H, Chen Z, Ao W, Shi P.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Adaptive Neural Network Robust Control of FOG with Output Constraints. [PDF]
Biomimetics (Basel)Liu S, Lian B, Ma J, Ding X, Li H.
europepmc +1 more source
Robust Control Allocation for Space Inertial Sensor under Test Mass Release Phase with Overcritical Conditions. [PDF]
Sensors (Basel), 2023 Zhang J, Zhang Y, Tao W, Lu Z, Lin M.
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source