Results 41 to 50 of about 11,839,721 (284)
Journal of the Royal Statistical Society Series B: Statistical Methodology, 2009 SummaryWe study the construction of experimental designs, the purpose of which is to aid in the discrimination between two possibly non-linear regression models, each of which might be only approximately specified. A rough description of our approach is that we impose neighbourhood structures on each regression response and determine the members of ...
openaire +1 more source
Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids
Pediatric Blood &Cancer, EarlyView.ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz +12 more
wiley +1 more source
IEEE AccessThe rotor eccentricity and manufacturing tolerances caused by unavoidable uncertainties in the process of manufacturing deteriorate the cogging torque of permanent magnet (PM) motors. To guide the design and optimization of PM motors, this paper proposes
Yue Zhao +4 more
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Uncertainty quantification and reduction using Jacobian and Hessian information
Design Science, 2021 Robust design methods have expanded from experimental techniques to include sampling methods, sensitivity analysis and probabilistic optimisation. Such methods typically require many evaluations.
Josefina Sánchez, Kevin Otto
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
wiley +1 more source
A robust design methodology suitable for application to one-off products [PDF]
, 1998 Robust design is an activity of fundamental importance when designing large, complex, one-off engineering products. Work is described which is concerned with the application of the theory of design of experiments and stochastic optimization methods to ...
Whitfield, R.I. +3 more
core +4 more sources
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Robust optimization utilizing the second-order design sensitivity information [PDF]
, 2010 This paper presents an effective methodology for robust optimization of electromagnetic devices. To achieve the goal, the method improves the robustness of the minimum of the objective function chosen as a design solution by minimizing the second-order ...
Kim, Heung-Geun +11 more
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The Role of Biowaste: A Multi-Objective Optimization Platform for Combined Heat, Power and Fuel
Frontiers in Energy Research, 2021 Biomass, bioenergy and negative emission technologies are inherent to the future design of energy systems. Urban clusters have a growing demand for fuel, heat and electricity, which is both a challenge and an opportunity for biomass-based technologies ...
Rafael Castro-Amoedo +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source