Results 91 to 100 of about 14,976,458 (288)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Transient Wave‐Based Data Assimilation for Localizing Multiple Leaks in Water Pipe Networks
Water Resources ResearchDue to aging without timely renewal, hidden leaks continually occur in urban water distribution systems. Time‐domain full‐waveform inversion is a robust and flexible method for localizing multiple leaks in water pipe networks. However, as a deterministic
Qiuru Chen +3 more
doaj +1 more source
Robust estimation of nonlinear model coefficients for wireless power amplifiers
, 2011 In this paper, the general formulas which relate the analytical expression for the fundamental frequency signal and the in-band distortion components to the order of a power amplifier (PA) polynomial modelare derived.
Tarczynski, A. +7 more
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Robust Control: A Note on the Timing of Model Uncertainty [PDF]
In this note a one-state, one-control variable quadratic linear problem with robust control and discount factor is developed to examine the optimal response of the first-period control to changes in future model uncertainty.
Arnulfo Rodriguez
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Nature CommunicationsHigh-precision metrology has laid the foundation for semiconductor fabrication and life sciences. However, existing displacement measurement approaches are incapable of performing flexible probing within complex equipment interiors. Here, we present a in
Lele Wang +10 more
doaj +1 more source
Robust estimation of the vector autoregressive model by a trimmed least squares procedure. [PDF]
The vector autoregressive model is very popular for modeling multiple time series. Estimation of its parameters is done by a least squares procedure. However, this estimation method is unreliable when outliers are present in the data, and there is a need
Croux, Christophe, Joossens, Kristel
core