Results 41 to 50 of about 14,976,458 (288)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Where Does mBERT Understand Code-Mixing? Layer-Dependent Performance on Semantic Tasks
IEEE AccessSemantic tasks like lexical relation prediction and word analogy are crucial for deep language understanding, yet pose significant challenges when applied to code-mixed text, where multiple languages are interwoven. This study investigates the ability of
Aditya Somani +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels
Cell Reports, 2017 Lipid regulation of ion channels by low-abundance signaling lipids phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid (PA) has emerged as a central cellular mechanism for controlling ion channels and the excitability of nerves.
Cerrone Cabanos +3 more
doaj +1 more source
Известия высших учебных заведений России: Радиоэлектроника, 2020 Introduction. A hardware basis of modern Advanced Driver Assistance Systems (ADAS) consists of millimeterrange radars, characterized by a relatively short range (meters – tens of meters). At the same time, improving of traffic safety requires to increase
N. V. Sokolik
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Optics Express, 2012 Detection of fluorescence from a low quantum yield fluorophore is challenging for a fiber-optic probe, especially when an inexpensive and robust construction is desired. We propose a conceptually straightforward theoretical model to optimize the factors affecting the fluorescence-capture capability of a bifurcated/coaxial fiber-optic probe ...
Jianjun, Ma +4 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2021 Additional file 1 Figure S1–S7. Figure S1: Optimization of the diffBUM-HMM transition matrix: boxplots of prediction mismatch value over transition matrix perturbations for the 35S and Xist molecules. Figure S2: Enriched RBP binding motif search amongst the DRNs/DRRs detected by diffBUM-HMM and deltaSHAPE within the Xist molecule.
Marangio, Paolo +3 more
openaire +1 more source