Results 111 to 120 of about 5,238,545 (299)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Shift-Invariant Kernel Additive Modelling for Audio Source Separation

open access: yes, 2018
A major goal in blind source separation to identify and separate sources is to model their inherent characteristics. While most state-of-the-art approaches are supervised methods trained on large datasets, interest in non-data-driven approaches such as ...
Ewert, Sebastian   +3 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Tax Audit in Turkiye: Simulation and Estimations Based on Kernel and Weight Functions

open access: yesChaos Theory and Applications
This research examines the use of kernel estimation and $FindDistribution$ methods in $Mathematica$ software to analyze the ratio of taxpayer audits to total taxpayers, focusing on two large populations: one with approximately 80,000 audits per 100,000 ...
Mehmet Niyazi Çankaya, Murat Aydın
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Robustness properties of quasi-linear means with application to the Laspeyres and Paasche indices [PDF]

open access: yes, 2012
Li, Fang & Tian (1994) assert that special quasi-linear means should be preferred to the simple arithmetic mean for robustness properties. The strategy that is used to show robustness is completely detached from the concepts wellknown from the theory of ...
Ardelean, Vlad, Klein, Ingo
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Comparison of Internal Clustering Validation Indices for Prototype-Based Clustering

open access: yesAlgorithms, 2017
Clustering is an unsupervised machine learning and pattern recognition method. In general, in addition to revealing hidden groups of similar observations and clusters, their number needs to be determined.
Joonas Hämäläinen   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy