Results 111 to 120 of about 1,312,830 (302)
Network robustness: Implication, formulization and exploitation [PDF]
, 2016 Robustness refers to a system's capacity for maintaining some performance when the system's internal structure is perturbed. In previous study, network robustness, i.e., network structure robustness, includes both resistance capacity (connection ...
WenJun Zhang
core
Parasites lead to evolution of robustness against gene loss in host signaling networks [PDF]
, 2008 Many biological networks can maintain their function against single gene loss. However, the evolutionary mechanisms responsible for such robustness remain unclear.
Orkun S Soyer +6 more
core +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Ethical Theory and Moral Practice, 2018 Recently Philip Pettit (2015) has claimed that attachment, virtue, and respect are robust goods. Robust goods require not only the actual provision of certain associated ‘thin’ goods, but also the modally robust provision of these thin goods across a range of counterfactual situations. I focus my attention on Pettit’s account of the robust good of love,
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Robustness-Driven Resilience Evaluation of Self-Adaptive Software Systems [PDF]
, 2015 An increasingly important requirement for certain classes of software-intensive systems is the ability to self-adapt their structure and behavior at run-time when reacting to changes that may occur to the system, its environment, or its goals.
de Lemos, Rogerio +4 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Using Inferential Robustness to Establish the Security of an Evidence Claim [PDF]
, 2011 Evidence claims depend on fallible assumptions. This paper discusses inferential robustness as a strategy for justifying evidence claims in spite of this fallibility.
Staley, Kent
core
Towards Analyzing Semantic Robustness of Deep Neural Networks
, 2019 implementation of the paper: "Towards Analyzing Semantic Robustness of Deep Neural Networks" (ECCV 2020 ...
Abdullah Hamdi +3 more
core +1 more source