Results 91 to 100 of about 578,574 (323)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A direct experimental test of Ohno’s hypothesis
eLifeGene duplication drives evolution by providing raw material for proteins with novel functions. An influential hypothesis by Ohno (1970) posits that gene duplication helps genes tolerate new mutations and thus facilitates the evolution of new phenotypes ...
Ljiljana Mihajlovic +7 more
doaj +1 more source
Degrees and signatures of broken PT-symmetry in (non-uniform) lattices
, 2011 We investigate the robustness of parity- and time-reversal ($\mP\mT$) symmetric phase in an $N$-site lattice with position-dependent, parity-symmetric hopping function and a pair of imaginary, $\mP\mT$-symmetric impurities.
Joglekar, Yogesh N., Scott, Derek D.
core +1 more source
The Evolution of Robust Development and Homeostasis in Artificial Organisms
PLoS Computational Biology, 2008 During embryogenesis, multicellular animals are shaped via cell proliferation, cell rearrangement, and apoptosis. At the end of development, tissue architecture is then maintained through balanced rates of cell proliferation and loss. Here, we take an in silico approach to look for generic systems features of morphogenesis in multicellular animals that
David Basanta +2 more
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution
Molecular Systems Biology, 2010 What determines the rate of protein evolution is a fundamental question in biology. Recent genomic studies revealed a surprisingly strong anticorrelation between the expression level of a protein and its rate of sequence evolution.
Jian‐Rong Yang +2 more
doaj +1 more source
Research on a Dynamic Virus Propagation Model to Improve Smart Campus Security
IEEE Access, 2018 This paper focuses on the security and robustness of smart campuses by studying a virus propagation model. Establishing a model that reflects the epidemiological transmission mechanism is a primary method for studying disease outbreaks and control ...
Lei Wang +3 more
doaj +1 more source
Survival and innovation: The role of mutational robustness in evolution [PDF]
Biochimie, 2015 Biological systems are resistant to perturbations caused by the environment and by the intrinsic noise of the system. Robustness to mutations is a particular aspect of robustness in which the phenotype is resistant to genotypic variation. Mutational robustness has been linked to the ability of the system to generate heritable genetic variation (a ...
openaire +6 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source