Results 81 to 90 of about 578,574 (323)
Epistasis as a determinant of the HIV-1 protease's robustness to mutation. [PDF]
PLoS ONE, 2014 The robustness of phenotypes to mutation is critical to protein evolution; robustness may be an adaptive trait if it promotes evolution. We hypothesised that native proteins subjected to natural selection in vivo should be more robust than proteins ...
Elena Capel +2 more
doaj +1 more source
Accelerated adiabatic quantum gates: optimizing speed versus robustness
, 2019 We develop new protocols for high-fidelity single qubit gates that exploit and extend theoretical ideas for accelerated adiabatic evolution. Our protocols are compatible with qubit architectures with highly isolated logical states, where traditional ...
Clerk, A., Ribeiro, H.
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Quantum localization bounds Trotter errors in digital quantum simulation
, 2019 A fundamental challenge in digital quantum simulation (DQS) is the control of an inherent error, which appears when discretizing the time evolution of a quantum many-body system as a sequence of quantum gates, called Trotterization.
Hauke, P., Heyl, M., Zoller, P.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2011 In this paper, we study periodic boundary value problems for a class of linear fractional evolution equations involving the Caputo fractional derivative.
JinRong Wang, Yong Zhou, Michal Fečkan
doaj +1 more source
Sub-Doppler resonances in the back-scattered light from random porous media infused with Rb vapor
, 2013 We report on the observation of sub-Doppler resonances on the back-scattered light from a random porous glass medium with rubidium vapor filling its interstices.
Bloch, D. +5 more
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source