Results 121 to 130 of about 548,676 (308)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Evolution of Robust Developmental Neural Networks [PDF]

open access: bronze, 2004
Alan N. Hampton, Christoph Adami
openalex   +1 more source

Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication [PDF]

open access: green, 2023
Dipak Patel   +8 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

High-Order Numerical-Relativity Simulations of Binary Neutron Stars [PDF]

open access: yes, 2015
We report simulations of the inspiral and merger of binary neutron stars performed with \texttt{WhiskyTHC}, the first of a new generation of numerical relativity codes employing higher than second-order methods for both the spacetime and the hydrodynamic
Galeazzi, Filippo   +2 more
core   +2 more sources

Plasticity and robustness in development and evolution [PDF]

open access: yesInternational Journal of Epidemiology, 2012
Patrick, Bateson, Peter, Gluckman
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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