Results 141 to 150 of about 548,676 (308)
The relationship between robustness and evolution
, 2018 Abstract Developmental robustness (canalization) is a common attribute of traits in multi-cellular organisms. High robustness ensures the reproducibility of phenotypes in the face of environmental and developmental noise, but it also dampens the expression of genetic mutation, the fuel for adaptive evolution. A reduction in robustness may therefore be
Jiang, Pengyao +2 more
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FEBS Open Bio, EarlyView.This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li +10 more
wiley +1 more source
Constraint propagation of
, 2011 Takuya Tsuchiya, Gen Yoneda, H. Shinkai
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Co-evolution, Determinism and Robustness
, 1999 Robustness has long been recognised as a critical issue for coevolutionary learning. It has been achieved in a number of cases, though usually in domains which involve some form of non-determinism. We examine a deterministic domain - a pseudo real-time two-player game called Tron - and evolve a neural network player using a simple hill-climbing ...
A.D. Blair, Elizabeth Sklar, P. Funes
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Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Evolution of a high-performance and functionally robust musculoskeletal system in salamanders
, 2020 Stephen M. Deban +5 more
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Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Toward a Robust Estimate of the Merger Rate Evolution Using Near‐IR Photometry [PDF]
, 2008 A. Rawat +3 more
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